Organic room-temperature phosphorescence materials for bioimaging

Organic room-temperature phosphorescence (RTP) materials are currently the focus of research in the field of bioimaging. In comparison with the conventional imaging modalities based on organic fluorescent dyes, RTP materials with long lifetime enable time-resolved imaging to improve the imaging reso...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2023-05, Vol.59 (36), p.5329-5342
Main Authors: Zhang, Yahui, Li, Hairong, Yang, Mengdie, Dai, Wenbo, Shi, Jianbing, Tong, Bin, Cai, Zhengxu, Wang, Zhouyu, Dong, Yuping, Yu, Xiaoqi
Format: Article
Language:English
Subjects:
Controllability
Fluorescent Dyes
Host-guest materials
Image resolution
Medical imaging
Nanoparticles
Optimization
Phosphorescence
Room temperature
Supramolecular compounds
Temperature
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Summary:Organic room-temperature phosphorescence (RTP) materials are currently the focus of research in the field of bioimaging. In comparison with the conventional imaging modalities based on organic fluorescent dyes, RTP materials with long lifetime enable time-resolved imaging to improve the imaging resolution by avoiding autofluorescence. In this review, we will start with summarizing strategies for achieving high performance RTP materials for bioimaging, including the development of RTP-compounds, host-guest doping materials, and supramolecular assemblies. We then discuss the optimization of nanonization processes to obtain RTP nanoparticles with controllable size, high dispersibility, and improved stability. The differences between top-down and bottom-up approaches are further described. Finally, we briefly introduce the emerging methods for preparing RTP materials for bioimaging. Organic room-temperature phosphorescence (RTP) materials are currently the focus of research in the field of bioimaging. High performance of RTP materials and optimization in the preparation process of RTP nanoparticles are both important.
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc00923h