A Future Blood Test to Detect Cerebral Aneurysms

Intracranial aneurysms are reported to affect 2–5% of the population. Despite advances in the surgical management of this disease, diagnostic technologies have marginally improved and still rely on expensive or invasive imaging procedures. Currently, there is no blood-based test to detect cerebral a...

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Bibliographic Details
Published in:Cellular and molecular neurobiology 2023-08, Vol.43 (6), p.2697-2711
Main Authors: Nowicki, Kamil W., Mittal, Aditya M., Abou-Al-Shaar, Hussam, Rochlin, Emma K., Lang, Michael J., Gross, Bradley A., Friedlander, Robert M.
Format: Article
Language:English
Subjects:
Aneurysm
Biomedical and Life Sciences
Biomedicine
Blood tests
Cell Biology
Humans
Inflammation
Intracranial Aneurysm - diagnosis
Neurobiology
Neurosciences
Proteomics
Review Paper
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Summary:Intracranial aneurysms are reported to affect 2–5% of the population. Despite advances in the surgical management of this disease, diagnostic technologies have marginally improved and still rely on expensive or invasive imaging procedures. Currently, there is no blood-based test to detect cerebral aneurysm formation or quantify the risk of rupture. The aim of this review is to summarize current literature on the mechanism of aneurysm formation, specifically studies relating to inflammation, and provide a rationale and commentary on a hypothetical future blood-based test. Efforts should be focused on clinical-translational approaches to create an assay to screen for cerebral aneurysm presence and risk-stratify patients to allow for superior treatment timing and management. Graphical Abstract Cerebral Aneurysm Blood Test Considerations: There are multiple caveats to development of a putative blood test to detect cerebral aneurysm presence.
ISSN:0272-4340
1573-6830
DOI:10.1007/s10571-023-01346-4