The Role of the Soluble Interleukin-6 Receptor in the Progression of Nonalcoholic Fatty Liver Disease

The blood level of soluble IL-6 receptor was measured in patients with different clinical and morphological forms of nonalcoholic fatty liver disease and healthy donors. The relationship of the soluble IL-6 receptor with the content of IL-6, the level of the IL6 gene mRNA, and a number of markers of...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2023-03, Vol.174 (5), p.628-633
Main Authors: Kurbatova, I. V., Topchieva, L. V., Dudanova, O. P., Shipovskaya, A. A.
Format: Article
Language:English
Subjects:
Analysis
Apoptosis
Biomedical and Life Sciences
Biomedicine
Blood levels
Cell Biology
Cirrhosis
Development and progression
Disease Progression
Fatty liver
Hepatocytes
Humans
Interleukin 6
Interleukin 6 receptors
Interleukins
Internal Medicine
Laboratory Medicine
Leukocytes
Liver - pathology
Liver cirrhosis
Liver Cirrhosis - pathology
Liver diseases
mRNA
Non-alcoholic Fatty Liver Disease - genetics
Pathology
Peripheral blood
Receptors, Interleukin-6
Steatosis
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Summary:The blood level of soluble IL-6 receptor was measured in patients with different clinical and morphological forms of nonalcoholic fatty liver disease and healthy donors. The relationship of the soluble IL-6 receptor with the content of IL-6, the level of the IL6 gene mRNA, and a number of markers of hepatocyte and peripheral blood leukocyte apoptosis was assessed. It has been established for the first time that progression of nonalcoholic fatty liver disease is associated with changes in the level of soluble IL-6 receptor in the blood. In patients with high activity of nonalcoholic steatohepatitis and liver cirrhosis, the blood concentration of soluble IL-6 receptor sharply decreased in comparison with the earlier stages of progression of nonalcoholic fatty liver disease (liver steatosis, nonalcoholic steatohepatitis of weak and moderate activity). This allows considering the decrease in this indicator as a new diagnostic marker for distinguishing nonalcoholic steatohepatitis of high activity from weak and moderate activity. A close correlation between changes in the level of soluble IL-6 receptor and apoptosis of peripheral blood leukocytes and hepatocytes was revealed.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-023-05759-5