The evolution of non-small cell lung cancer metastases in TRACERx

Metastatic disease is responsible for the majority of cancer-related deaths 1 . We report the longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from 421 prospectively recruited patients in TRACERx who developed metastatic disease, compared with a control cohort of...

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Published in:	Nature (London) 2023-04, Vol.616 (7957), p.534-542
Main Authors:	Al Bakir, Maise, Huebner, Ariana, Martínez-Ruiz, Carlos, Grigoriadis, Kristiana, Watkins, Thomas B. K., Pich, Oriol, Moore, David A., Veeriah, Selvaraju, Ward, Sophia, Laycock, Joanne, Johnson, Diana, Rowan, Andrew, Razaq, Maryam, Akther, Mita, Naceur-Lombardelli, Cristina, Prymas, Paulina, Toncheva, Antonia, Hessey, Sonya, Dietzen, Michelle, Colliver, Emma, Frankell, Alexander M., Bunkum, Abigail, Lim, Emilia L., Karasaki, Takahiro, Abbosh, Christopher, Hiley, Crispin T., Hill, Mark S., Cook, Daniel E., Wilson, Gareth A., Salgado, Roberto, Nye, Emma, Stone, Richard Kevin, Fennell, Dean A., Price, Gillian, Kerr, Keith M., Naidu, Babu, Middleton, Gary, Summers, Yvonne, Lindsay, Colin R., Blackhall, Fiona H., Cave, Judith, Blyth, Kevin G., Nair, Arjun, Ahmed, Asia, Taylor, Magali N., Procter, Alexander James, Falzon, Mary, Lawrence, David, Navani, Neal, Thakrar, Ricky M., Janes, Sam M., Papadatos-Pastos, Dionysis, Forster, Martin D., Lee, Siow Ming, Ahmad, Tanya, Quezada, Sergio A., Peggs, Karl S., Van Loo, Peter, Dive, Caroline, Hackshaw, Allan, Birkbak, Nicolai J., Zaccaria, Simone, Jamal-Hanjani, Mariam, McGranahan, Nicholas, Swanton, Charles
Format:	Article
Language:	English
Subjects:	45 45/22 45/23 631/114 631/181/2474 631/208/69 631/67/1612/1350 631/67/322 Cancer therapies Carcinoma, Non-Small-Cell Lung - pathology Clonal Evolution Clone Cells - pathology Cloning Cohort Studies Disease control Disease Progression Divergence Evolution Evolution, Molecular Genomes Humanities and Social Sciences Humans Lung cancer Lung diseases Lung Neoplasms - pathology Lymph nodes Lymphatic system Mann-Whitney U test Metastases Metastasis multidisciplinary Mutation Neoplasm Metastasis - diagnosis Neoplasm Metastasis - pathology Neoplasm Recurrence, Local Non-small cell lung carcinoma Patients Phylogenetics Positive selection Quality control Sampling Science Science (multidisciplinary) Small cell lung carcinoma Smoking Tumors
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