Insight into the transcription factors regulating Ischemic stroke and glioma in response to shared stimuli

• Published in: Seminars in cancer biology 2023-07, Vol.92, p.102-127
• Main Authors: Waseem, Arshi, Rashid, Summya, Rashid, Khalid, Khan, Mohsin Ali, Khan, Rehan, Haque, Rizwanul, Seth, Pankaj, Raza, Syed Shadab
• Format: Article
• Language: English
• Subjects: Blood-tumor barrier; Brain Neoplasms - complications; Brain Neoplasms - genetics; Cancer; Glioma; Glioma - complications; Glioma - genetics; Humans; Ischemic Stroke; Stroke - genetics; Transcription factors; Transcription Factors - genetics; Transcription Factors - metabolism
• ISSN: 1044-579X; 1096-3650
• DOI: 10.1016/j.semcancer.2023.04.006

Cerebral ischemic stroke and glioma are the two leading causes of patient mortality globally. Despite physiological variations, 1 in 10 people who have an ischemic stroke go on to develop brain cancer, most notably gliomas. In addition, glioma treatments have also been shown to increase the risk of ischemic strokes. Stroke occurs more frequently in cancer patients than in the general population, according to traditional literature. Unbelievably, these events share multiple pathways, but the precise mechanism underlying their co-occurrence remains unknown. Transcription factors (TFs), the main components of gene expression programmes, finally determine the fate of cells and homeostasis. Both ischemic stroke and glioma exhibit aberrant expression of a large number of TFs, which are strongly linked to the pathophysiology and progression of both diseases. The precise genomic binding locations of TFs and how TF binding ultimately relates to transcriptional regulation remain elusive despite a strong interest in understanding how TFs regulate gene expression in both stroke and glioma. As a result, the importance of continuing efforts to understand TF-mediated gene regulation is highlighted in this review, along with some of the primary shared events in stroke and glioma.