Therapeutic strategies and clinical evolution of patients with infantile fibrosarcoma: a unique paediatric case series

Background Infantile fibrosarcoma is the most frequent soft tissue sarcoma in newborns or children under one year of age. This tumour often implies high local aggressiveness and surgical morbidity. The large majority of these patients carry the ETV6–NTRK3 oncogenic fusion. Hence, the TRK inhibitor l...

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Published in:Clinical & translational oncology 2023-11, Vol.25 (11), p.3307-3311
Main Authors: Corral Sánchez, María Dolores, Jiménez Carrascoso, Raquel, Rubio Aparicio, Pedro, Plaza López de Sabando, Diego, Sastre Urgelles, Ana, Pozo-Kreilinger, José Juan, López Gutiérrez, Juan Carlos, Gómez Cervantes, Manuel, Ortiz Cruz, Eduardo José, Pérez-Martínez, Antonio
Format: Article
Language:English
Subjects:
Brief Research Article
Medicine
Medicine & Public Health
Oncology
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Summary:Background Infantile fibrosarcoma is the most frequent soft tissue sarcoma in newborns or children under one year of age. This tumour often implies high local aggressiveness and surgical morbidity. The large majority of these patients carry the ETV6–NTRK3 oncogenic fusion. Hence, the TRK inhibitor larotrectinib emerged as an efficacious and safe alternative to chemotherapy for NTRK fusion-positive and metastatic or unresectable tumours. However, real-world evidence is still required for updating soft-tissue sarcoma practice guidelines. Objective To report our experience with the use of larotrectinib in pediatric patients. Methods Our case series shows the clinical evolution of 8 patients with infantile fibrosarcoma under different treatments. All patients enrolled in this study received informed consent for any treatment. Results Three patients received larotrectinib in first line. No surgery was needed with larotrectinib, which led to the rapid and safe remission of tumours, even in unusual anatomical locations. No significant adverse effects were observed with larotrectinib. Conclusion Our case series supports that larotrectinib may be a therapeutic option for newborn and infant patients with infantile fibrosarcoma, especially in uncommon locations.
ISSN:1699-3055
1699-3055
DOI:10.1007/s12094-023-03175-9