Autocatalytically hydroxyl-producing composite wound dressing for bacteria-infected wound healing

• Published in: Nanomedicine 2023-07, Vol.51, p.102683-102683, Article 102683
• Main Authors: Zhang, Pinrui, Xu, Xiaomu, He, Wangmei, Li, Hong, Huang, Yue, Wu, Gang
• Format: Article
• Language: English
• Subjects: Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial; Autocatalytic; Bacteria; Bandages - microbiology; Glucose; Hydroxyl radical; Metal-organic framework nanozyme; Methicillin-Resistant Staphylococcus aureus; Mice; Wound dressing; Wound Healing; Wound Infection - therapy
• ISSN: 1549-9634; 1549-9642
• DOI: 10.1016/j.nano.2023.102683

The creation of wound dressings with low drug resistance and broad-spectrum antibacterial capability is a key topic of scientific interest. To achieve this, a bactericidal wound dressing with the capacity to autocatalytically produce hydroxyl radicals (OH) was developed. The wound dressing was an electrospun PCL/gelatin/glucose composite fiber mesh (PGD) with functional iron-containing metal-organic framework (Fe-MOF) nanozymes. These functional nanozymes (G@Fe) were formed by coupling glucose oxidase (GOx) and Fe-MOF through amide bonds. These nanozymes enabled the conversion of glucose released from the PGD composite mesh into hydroxyl radicals via an autocatalytic cascade reaction to destroy bacteria. The antibacterial efficiency of wound dressings and their stimulation of tissue regeneration were assessed using a MRSA-infected skin wound infection model on the back of SD mice. The G@Fe/PGD wound dressing exhibited improved wound healing capacity and had comparable biosafety to commercial silver-containing dressings, suggesting a potential replacement in the future. A self-activated antimicrobial wound dressing was created based on the cascade reaction between glucose and glucose oxidase (GOx). The wound dressing was made by depositing hybrid Fe-MOF/GOx (G@Fe) peroxide-like nanozyme on PCL/gelatin/d-glucose (PGD) electrospun composite fiber mesh, which generated OH for an antimicrobial effect. The bacterial-infected wound model was used to gauge the wound healing rate which demonstrated the G@Fe/PGD would dressing had an excellent wound healing capability. [Display omitted]