The effects of flavonoids in experimental sepsis: A systematic review and meta‐analysis

Sepsis is a host's dysregulated immune response to an infection associated with systemic inflammation and excessive oxidative stress, which can cause multiple organ failure and death. The literature suggests that flavonoids, a broad class of secondary plant metabolites, have numerous biological...

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Published in:Phytotherapy research 2023-06, Vol.37 (6), p.2531-2551
Main Authors: Oliveira Rodrigues Junior, Edinildo, Santana, Izabel Rodrigues, Durço, Aimée Obolari, Conceição, Lino Sérgio Rocha, Barreto, André Sales, Menezes, Igor Alexandre Cortês, Roman‐Campos, Danilo, Santos, Márcio Roberto Viana
Format: Article
Language:English
Subjects:
Animals
Apoptosis
CLP model
Complications
flavonoid
Flavonoids
Flavonoids - pharmacology
Flavonoids - therapeutic use
Immune response
Immunosuppressive agents
Inflammation
Inflammation - drug therapy
Inflammatory response
Interleukins
Meta-analysis
Metabolites
Oxidative Stress
Reviews
Sepsis
Sepsis - drug therapy
Survival
survival rate
Tumor Necrosis Factor-alpha - pharmacology
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Summary:Sepsis is a host's dysregulated immune response to an infection associated with systemic inflammation and excessive oxidative stress, which can cause multiple organ failure and death. The literature suggests that flavonoids, a broad class of secondary plant metabolites, have numerous biological activities which can be valuable in the treatment of sepsis. This study aimed to review the effects of flavonoids on experimental sepsis, focusing mainly on survival rate, and also summarizing information on its mechanisms of action. We searched in the main databases up to November 2022 using relevant keywords, and data were extracted and analyzed qualitatively and quantitatively. Thirty‐two articles met the study criteria for review and 29 for meta‐analysis. Overall, 30 different flavonoids were used in the studies. The flavonoids were able to strongly inhibit inflammatory response by reducing the levels of important pro‐inflammatory mediators, for example, tumor necrosis factor‐alpha and interleukin‐1β, oxidative stress, and showed antibacterial and anti‐apoptotic actions. The meta‐analysis found an increase of 50% in survival rate of the animals treated with flavonoids. They appear to act as multi‐target drugs and may be an excellent therapeutic alternative to reduce a number of the complications caused by sepsis, and consequently, to improve survival rate.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.7846