Determination of solubility of ZnCl2 in hydrochloric acid solutions for 68Ga production in liquid target

The solubility of zinc-chloride (ZnCl2) in different concentrations of hydrochloric acid have been experimentally studied. Solubility for anhydrous ZnCl2 was found to be the highest in 3–6 M hydrochloric acid solution. Elevating the temperature of the solvent further increased solubility albeit with...

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Bibliographic Details
Published in:Applied radiation and isotopes 2023-07, Vol.197, p.110802-110802, Article 110802
Main Authors: Fodor, Mátyás, Szűcs, Zoltán
Format: Article
Language:English
Subjects:
Gallium-68
HCl
Hydrochloric acid
Solubility
Zinc-chloride
ZnCl2
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Summary:The solubility of zinc-chloride (ZnCl2) in different concentrations of hydrochloric acid have been experimentally studied. Solubility for anhydrous ZnCl2 was found to be the highest in 3–6 M hydrochloric acid solution. Elevating the temperature of the solvent further increased solubility albeit with diminishing returns above 50 °C when the evaporation of hydrochloric acid increases. The best solubility was found to be 26.1 ± 1.17 M in 6 M hydrochloric acid at 50 °C. This information is important for further studies which will be aimed at producing and testing a liquid target for the irradiation of [68Zn]ZnCl2 solution in hydrochloric acid. The testing will involve pressure, irradiation time, acquired activity and other parameters. In the current paper we only describe the experimental results for the solubility measurements for ZnCl2 in different hydrochloric acid concentrations, 68Ga production is not carried out yet. •ZnCl2 solubility in HCl acid.•pH and temperature dependency of solubility.•Optimizing liquid target solution for 68Ga cyclotron production.•Solubility measurement for hydroscopic and deliquescent material.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2023.110802