Fabrication of antibacterial polydopamine-carboxymethyl cellulose-Ag nanoparticle hydrogel coating for urinary catheters

Urinary tract infections caused by catheter insertion are prevalent in hospital clinics, which can induce serious complications such as bacteriuria and sepsis, and even lead to patient death. The disposable catheters currently used in clinical practice suffer from poor biocompatibility and high infe...

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Bibliographic Details
Published in:Journal of biomaterials applications 2023-07, Vol.38 (1), p.73-84
Main Authors: Cai, Yongwei, Gu, Ronghua, Dong, Yuhang, Zhao, Qi, Zhang, Ke, Cheng, Changyuan, Yang, Hong, Li, Jianxiang, Yuan, Xinggen
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Carboxymethylcellulose Sodium
Escherichia coli
Humans
Hydrogels
Metal Nanoparticles
Silver - pharmacology
Staphylococcus aureus
Urinary Catheters
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Summary:Urinary tract infections caused by catheter insertion are prevalent in hospital clinics, which can induce serious complications such as bacteriuria and sepsis, and even lead to patient death. The disposable catheters currently used in clinical practice suffer from poor biocompatibility and high infection rate. In this paper, we developed a polydopamine (PDA)-carboxymethylcellulose (CMC)-Ag nanoparticles (AgNPs) coating with both good antibacterial and anti-adhesion properties to bacteria on the surfaces of a disposable medical latex catheter by a simple dipping method. The antibacterial efficiency of the coated catheters against Gram-negative E. coli and Gram-positive S. aureus bacteria was evaluated with both inhibition zone tests and fluorescence microscopy. Compared with the untreated catheter, the PDA-CMC-AgNPs coated catheters showed both good antibacterial and anti-adhesion properties to bacteria, which inhibited the adhesion of live bacteria and dead bacteria by 99.0% and 86.6%, respectively. This novel PDA-CMC-AgNPs composite hydrogel coating has great potential in applications in catheters and other biomedical devices to reduce infections. Graphical Abstract
ISSN:0885-3282
1530-8022
DOI:10.1177/08853282231173576