Prevalence and Antifungal Susceptibility of Sporothrix species in Guangzhou, Southern China

Introduction Sporotrichosis is a subcutaneous and chronic infection caused by traumatic inoculation of pathogenic sporothrix species, usually infecting the skins and subcutaneous tissues of humans and animals. However, the lack of epidemiological data required further molecular identification to des...

Full description

Saved in:
Bibliographic Details
Published in:Mycoses 2023-08, Vol.66 (8), p.651-658
Main Authors: Lin, Li, Huang, Junhao, Fang, Junyue, Li, Jiahao, Cai, Wenying, Zhang, Jing, Lu, Sha
Format: Article
Language:English
Subjects:
Amphotericin B
Animals
Antifungal agents
Antifungal Agents - pharmacology
Antifungal Agents - therapeutic use
antifungal susceptibility
Calmodulin
China - epidemiology
Chronic infection
Correlation analysis
Epidemiology
Fluconazole
Flucytosine
Humans
Inoculation
Introduced species
Itraconazole
Microbial Sensitivity Tests
molecular identification
mycelial phase
Prevalence
Sensitivity analysis
Sporothrix
Sporothrix - genetics
Sporotrichosis
Sporotrichosis - drug therapy
Sporotrichosis - epidemiology
Sporotrichosis - microbiology
Terbinafine
Terbinafine - pharmacology
Voriconazole
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction Sporotrichosis is a subcutaneous and chronic infection caused by traumatic inoculation of pathogenic sporothrix species, usually infecting the skins and subcutaneous tissues of humans and animals. However, the lack of epidemiological data required further molecular identification to describe the distribution of this fungus in our region. In this study, forty‐eight clinical sporothrix isolated from Sun Yat‐Sen Memorial Hospital were classified, and the susceptibility of each strain to seven antifungal agents was determined. Methods Forty strains of S. globosa and eight strains of S. shenkshii were identified via colony morphology and PCR sequencing of calmodulin gene. Results Antifungal susceptibility tests of the mycelial phase in vitro showed terbinafine (TRB) and luliconazole (LULI) were the most effective, followed by itraconazole (ITZ) and amphotericin B (AMB). By contrast, voriconazole (VCZ), 5‐flucytosine (5FC) and fluconazole (FCZ) have low efficacy with high MIC. Conclusion Our results showed a predominantly S. globosa infection trend in southern China. Simultaneously, sporothrix is sensitive to TRB, LULI, ITZ and AMB whereas resistant to FCZ. This study firstly reports antifungal sensitivity test in vitro and epidemiological correlation analysis of sporothrix in southern China, and also the first time to find that sporothrix is sensitive to LULI.
ISSN:0933-7407
1439-0507
DOI:10.1111/myc.13599