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Prevalence and Antifungal Susceptibility of Sporothrix species in Guangzhou, Southern China
Introduction Sporotrichosis is a subcutaneous and chronic infection caused by traumatic inoculation of pathogenic sporothrix species, usually infecting the skins and subcutaneous tissues of humans and animals. However, the lack of epidemiological data required further molecular identification to des...
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| Published in: | Mycoses 2023-08, Vol.66 (8), p.651-658 |
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| container_end_page | 658 |
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| container_title | Mycoses |
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| creator | Lin, Li Huang, Junhao Fang, Junyue Li, Jiahao Cai, Wenying Zhang, Jing Lu, Sha |
| description | Introduction
Sporotrichosis is a subcutaneous and chronic infection caused by traumatic inoculation of pathogenic sporothrix species, usually infecting the skins and subcutaneous tissues of humans and animals. However, the lack of epidemiological data required further molecular identification to describe the distribution of this fungus in our region. In this study, forty‐eight clinical sporothrix isolated from Sun Yat‐Sen Memorial Hospital were classified, and the susceptibility of each strain to seven antifungal agents was determined.
Methods
Forty strains of S. globosa and eight strains of S. shenkshii were identified via colony morphology and PCR sequencing of calmodulin gene.
Results
Antifungal susceptibility tests of the mycelial phase in vitro showed terbinafine (TRB) and luliconazole (LULI) were the most effective, followed by itraconazole (ITZ) and amphotericin B (AMB). By contrast, voriconazole (VCZ), 5‐flucytosine (5FC) and fluconazole (FCZ) have low efficacy with high MIC.
Conclusion
Our results showed a predominantly S. globosa infection trend in southern China. Simultaneously, sporothrix is sensitive to TRB, LULI, ITZ and AMB whereas resistant to FCZ. This study firstly reports antifungal sensitivity test in vitro and epidemiological correlation analysis of sporothrix in southern China, and also the first time to find that sporothrix is sensitive to LULI. |
| doi_str_mv | 10.1111/myc.13599 |
| format | article |
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Sporotrichosis is a subcutaneous and chronic infection caused by traumatic inoculation of pathogenic sporothrix species, usually infecting the skins and subcutaneous tissues of humans and animals. However, the lack of epidemiological data required further molecular identification to describe the distribution of this fungus in our region. In this study, forty‐eight clinical sporothrix isolated from Sun Yat‐Sen Memorial Hospital were classified, and the susceptibility of each strain to seven antifungal agents was determined.
Methods
Forty strains of S. globosa and eight strains of S. shenkshii were identified via colony morphology and PCR sequencing of calmodulin gene.
Results
Antifungal susceptibility tests of the mycelial phase in vitro showed terbinafine (TRB) and luliconazole (LULI) were the most effective, followed by itraconazole (ITZ) and amphotericin B (AMB). By contrast, voriconazole (VCZ), 5‐flucytosine (5FC) and fluconazole (FCZ) have low efficacy with high MIC.
Conclusion
Our results showed a predominantly S. globosa infection trend in southern China. Simultaneously, sporothrix is sensitive to TRB, LULI, ITZ and AMB whereas resistant to FCZ. This study firstly reports antifungal sensitivity test in vitro and epidemiological correlation analysis of sporothrix in southern China, and also the first time to find that sporothrix is sensitive to LULI.</description><identifier>ISSN: 0933-7407</identifier><identifier>EISSN: 1439-0507</identifier><identifier>DOI: 10.1111/myc.13599</identifier><identifier>PMID: 37156262</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Amphotericin B ; Animals ; Antifungal agents ; Antifungal Agents - pharmacology ; Antifungal Agents - therapeutic use ; antifungal susceptibility ; Calmodulin ; China - epidemiology ; Chronic infection ; Correlation analysis ; Epidemiology ; Fluconazole ; Flucytosine ; Humans ; Inoculation ; Introduced species ; Itraconazole ; Microbial Sensitivity Tests ; molecular identification ; mycelial phase ; Prevalence ; Sensitivity analysis ; Sporothrix ; Sporothrix - genetics ; Sporotrichosis ; Sporotrichosis - drug therapy ; Sporotrichosis - epidemiology ; Sporotrichosis - microbiology ; Terbinafine ; Terbinafine - pharmacology ; Voriconazole</subject><ispartof>Mycoses, 2023-08, Vol.66 (8), p.651-658</ispartof><rights>2023 Wiley‐VCH GmbH.</rights><rights>2023 Wiley-VCH GmbH.</rights><rights>2023 Wiley‐VCH GmbH Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3139-41353f5b753c2af3115dd3cf411034b82b581cdcde714dfaa675a6cda6bcf3363</cites><orcidid>0000-0002-7068-9814 ; 0000-0003-0754-7503 ; 0000-0002-7339-7315</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37156262$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Li</creatorcontrib><creatorcontrib>Huang, Junhao</creatorcontrib><creatorcontrib>Fang, Junyue</creatorcontrib><creatorcontrib>Li, Jiahao</creatorcontrib><creatorcontrib>Cai, Wenying</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Lu, Sha</creatorcontrib><title>Prevalence and Antifungal Susceptibility of Sporothrix species in Guangzhou, Southern China</title><title>Mycoses</title><addtitle>Mycoses</addtitle><description>Introduction
Sporotrichosis is a subcutaneous and chronic infection caused by traumatic inoculation of pathogenic sporothrix species, usually infecting the skins and subcutaneous tissues of humans and animals. However, the lack of epidemiological data required further molecular identification to describe the distribution of this fungus in our region. In this study, forty‐eight clinical sporothrix isolated from Sun Yat‐Sen Memorial Hospital were classified, and the susceptibility of each strain to seven antifungal agents was determined.
Methods
Forty strains of S. globosa and eight strains of S. shenkshii were identified via colony morphology and PCR sequencing of calmodulin gene.
Results
Antifungal susceptibility tests of the mycelial phase in vitro showed terbinafine (TRB) and luliconazole (LULI) were the most effective, followed by itraconazole (ITZ) and amphotericin B (AMB). By contrast, voriconazole (VCZ), 5‐flucytosine (5FC) and fluconazole (FCZ) have low efficacy with high MIC.
Conclusion
Our results showed a predominantly S. globosa infection trend in southern China. Simultaneously, sporothrix is sensitive to TRB, LULI, ITZ and AMB whereas resistant to FCZ. This study firstly reports antifungal sensitivity test in vitro and epidemiological correlation analysis of sporothrix in southern China, and also the first time to find that sporothrix is sensitive to LULI.</description><subject>Amphotericin B</subject><subject>Animals</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - pharmacology</subject><subject>Antifungal Agents - therapeutic use</subject><subject>antifungal susceptibility</subject><subject>Calmodulin</subject><subject>China - epidemiology</subject><subject>Chronic infection</subject><subject>Correlation analysis</subject><subject>Epidemiology</subject><subject>Fluconazole</subject><subject>Flucytosine</subject><subject>Humans</subject><subject>Inoculation</subject><subject>Introduced species</subject><subject>Itraconazole</subject><subject>Microbial Sensitivity Tests</subject><subject>molecular identification</subject><subject>mycelial phase</subject><subject>Prevalence</subject><subject>Sensitivity analysis</subject><subject>Sporothrix</subject><subject>Sporothrix - genetics</subject><subject>Sporotrichosis</subject><subject>Sporotrichosis - drug therapy</subject><subject>Sporotrichosis - epidemiology</subject><subject>Sporotrichosis - microbiology</subject><subject>Terbinafine</subject><subject>Terbinafine - pharmacology</subject><subject>Voriconazole</subject><issn>0933-7407</issn><issn>1439-0507</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kEtLAzEURoMoWh8L_4AE3ChYzWOSdJZSfIGiUF2IiyGTSWxkmozJRK2_3mjVheDd3M3hcPgA2MboEOc7ms3VIaasLJfAABe0HCKGxDIYoJLSoSiQWAPrMT4hhEVJ-CpYowIzTjgZgIeboF9kq53SULoGHrvemuQeZQsnKSrd9ba2re3n0Bs46Xzw_TTYNxg7rayO0Dp4lqR7fJ_6dAAnPvVTHRwcT62Tm2DFyDbqre-_Ae5OT27H58PL67OL8fHlUFGcY4ucTg2rBaOKSEMxZk1DlSkwRrSoR6RmI6wa1WiBi8ZIyQWTXDWS18pQyukG2Ft4u-Cfk459NbM5vW2l0z7FioyyknNOREZ3_6BPPgWX6zJFCRZUMJKp_QWlgo8xaFN1wc5kmFcYVZ-LV3nx6mvxzO58G1M9080v-TNxBo4WwKtt9fx_U3V1P14oPwBit4qz</recordid><startdate>202308</startdate><enddate>202308</enddate><creator>Lin, Li</creator><creator>Huang, Junhao</creator><creator>Fang, Junyue</creator><creator>Li, Jiahao</creator><creator>Cai, Wenying</creator><creator>Zhang, Jing</creator><creator>Lu, Sha</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7068-9814</orcidid><orcidid>https://orcid.org/0000-0003-0754-7503</orcidid><orcidid>https://orcid.org/0000-0002-7339-7315</orcidid></search><sort><creationdate>202308</creationdate><title>Prevalence and Antifungal Susceptibility of Sporothrix species in Guangzhou, Southern China</title><author>Lin, Li ; Huang, Junhao ; Fang, Junyue ; Li, Jiahao ; Cai, Wenying ; Zhang, Jing ; Lu, Sha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3139-41353f5b753c2af3115dd3cf411034b82b581cdcde714dfaa675a6cda6bcf3363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Amphotericin B</topic><topic>Animals</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - pharmacology</topic><topic>Antifungal Agents - therapeutic use</topic><topic>antifungal susceptibility</topic><topic>Calmodulin</topic><topic>China - epidemiology</topic><topic>Chronic infection</topic><topic>Correlation analysis</topic><topic>Epidemiology</topic><topic>Fluconazole</topic><topic>Flucytosine</topic><topic>Humans</topic><topic>Inoculation</topic><topic>Introduced species</topic><topic>Itraconazole</topic><topic>Microbial Sensitivity Tests</topic><topic>molecular identification</topic><topic>mycelial phase</topic><topic>Prevalence</topic><topic>Sensitivity analysis</topic><topic>Sporothrix</topic><topic>Sporothrix - genetics</topic><topic>Sporotrichosis</topic><topic>Sporotrichosis - drug therapy</topic><topic>Sporotrichosis - epidemiology</topic><topic>Sporotrichosis - microbiology</topic><topic>Terbinafine</topic><topic>Terbinafine - pharmacology</topic><topic>Voriconazole</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Li</creatorcontrib><creatorcontrib>Huang, Junhao</creatorcontrib><creatorcontrib>Fang, Junyue</creatorcontrib><creatorcontrib>Li, Jiahao</creatorcontrib><creatorcontrib>Cai, Wenying</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Lu, Sha</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Mycoses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Li</au><au>Huang, Junhao</au><au>Fang, Junyue</au><au>Li, Jiahao</au><au>Cai, Wenying</au><au>Zhang, Jing</au><au>Lu, Sha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and Antifungal Susceptibility of Sporothrix species in Guangzhou, Southern China</atitle><jtitle>Mycoses</jtitle><addtitle>Mycoses</addtitle><date>2023-08</date><risdate>2023</risdate><volume>66</volume><issue>8</issue><spage>651</spage><epage>658</epage><pages>651-658</pages><issn>0933-7407</issn><eissn>1439-0507</eissn><abstract>Introduction
Sporotrichosis is a subcutaneous and chronic infection caused by traumatic inoculation of pathogenic sporothrix species, usually infecting the skins and subcutaneous tissues of humans and animals. However, the lack of epidemiological data required further molecular identification to describe the distribution of this fungus in our region. In this study, forty‐eight clinical sporothrix isolated from Sun Yat‐Sen Memorial Hospital were classified, and the susceptibility of each strain to seven antifungal agents was determined.
Methods
Forty strains of S. globosa and eight strains of S. shenkshii were identified via colony morphology and PCR sequencing of calmodulin gene.
Results
Antifungal susceptibility tests of the mycelial phase in vitro showed terbinafine (TRB) and luliconazole (LULI) were the most effective, followed by itraconazole (ITZ) and amphotericin B (AMB). By contrast, voriconazole (VCZ), 5‐flucytosine (5FC) and fluconazole (FCZ) have low efficacy with high MIC.
Conclusion
Our results showed a predominantly S. globosa infection trend in southern China. Simultaneously, sporothrix is sensitive to TRB, LULI, ITZ and AMB whereas resistant to FCZ. This study firstly reports antifungal sensitivity test in vitro and epidemiological correlation analysis of sporothrix in southern China, and also the first time to find that sporothrix is sensitive to LULI.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37156262</pmid><doi>10.1111/myc.13599</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7068-9814</orcidid><orcidid>https://orcid.org/0000-0003-0754-7503</orcidid><orcidid>https://orcid.org/0000-0002-7339-7315</orcidid></addata></record> |
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| subjects | Amphotericin B Animals Antifungal agents Antifungal Agents - pharmacology Antifungal Agents - therapeutic use antifungal susceptibility Calmodulin China - epidemiology Chronic infection Correlation analysis Epidemiology Fluconazole Flucytosine Humans Inoculation Introduced species Itraconazole Microbial Sensitivity Tests molecular identification mycelial phase Prevalence Sensitivity analysis Sporothrix Sporothrix - genetics Sporotrichosis Sporotrichosis - drug therapy Sporotrichosis - epidemiology Sporotrichosis - microbiology Terbinafine Terbinafine - pharmacology Voriconazole |
| title | Prevalence and Antifungal Susceptibility of Sporothrix species in Guangzhou, Southern China |
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