Long-term impact of pregnancy on renal function among Egyptian women with lupus nephritis: A case control study

Few studies tackled the long-term effect of pregnancy on lupus nephritis (LNs); thus, the study aimed to explore the long-term impact of pregnancy on renal outcomes in Egyptian patients with LN. Group I patients included females who had their first pregnancy after LN onset with ≥5 years elapsing aft...

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Bibliographic Details
Published in:Lupus 2023-06, Vol.32 (7), p.842-854
Main Authors: Attia, Doaa HS, Mokbel, Abir, Mohamed, Moataz Fatthy, Haggag, Hisham Mamdouh
Format: Article
Language:English
Subjects:
Case-Control Studies
Creatinine
Egypt - epidemiology
End-stage renal disease
Epidermal growth factor receptors
Female
Glomerular filtration rate
Humans
Kidney - physiology
Kidney diseases
Lupus
Lupus Erythematosus, Systemic
Lupus nephritis
Lupus Nephritis - complications
Lupus Nephritis - epidemiology
Nephritis
Pregnancy
Renal function
Renal Insufficiency, Chronic
Retrospective Studies
Risk Factors
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Summary:Few studies tackled the long-term effect of pregnancy on lupus nephritis (LNs); thus, the study aimed to explore the long-term impact of pregnancy on renal outcomes in Egyptian patients with LN. Group I patients included females who had their first pregnancy after LN onset with ≥5 years elapsing after delivery; group II patients included females who had never got pregnant for ≥7 years after LN onset. Data were retrospectively collected at baseline (T0) and the last visit (Tlast). The study included 43 patients in group I and 39 patients in group II. The comparisons between the two groups regarding the characteristics at Tlast showed no significant difference regarding the serum creatinine, estimated glomerular filtration rate (eGFR), renal component of SLICC/ACR Damage Index (SDI) as well as the rate of renal flares, new-onset chronic kidney disease (CKD), progressed CKD and end-stage renal disease. Multivariate regression analysis revealed that systemic hypertension and renal flares were predictors of new-onset/progressed CKD (p = 0.019, OR [95% CI] = 4 [1.3–13]; and 0.022, 13.8 [1.5–128.8], respectively) while pregnancy was not (p = 0.363). Paired comparisons between T0 and Tlast characteristics within each group revealed significant increment of serum creatinine, renal SDI and CKD prevalence; as well as decrement of eGFR in group I (p = 0.004,
ISSN:0961-2033
1477-0962
DOI:10.1177/09612033231174410