The causal links between gut microbiota and COVID‐19: A Mendelian randomization study

Several studies have shown a possible correlation between gut microbiota and COVID‐19. However, the cause‐and‐effect relationship between the two has not been investigated. We conducted a two‐sample Mendelian randomization study (MR) study using publicly available GWAS data. Inverse variance weighte...

Full description

Saved in:
Bibliographic Details
Published in:Journal of medical virology 2023-05, Vol.95 (5), p.e28784-n/a
Main Authors: Song, Jukun, Wu, Yadong, Yin, Xinhai, Ma, Hong, Zhang, Junmei
Format: Article
Language:English
Subjects:
Actinobacteria
causal relationship
COVID-19
Dietary Supplements
Gastrointestinal Microbiome - genetics
Genome-Wide Association Study
gut microbiota
Heterogeneity
Hospitalization
Humans
Intestinal microflora
Mendelian randomization
Mendelian Randomization Analysis
Microbiota
Microorganisms
Pleiotropy
Polymorphism, Single Nucleotide
Randomization
Sensitivity analysis
Variance analysis
Virology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Several studies have shown a possible correlation between gut microbiota and COVID‐19. However, the cause‐and‐effect relationship between the two has not been investigated. We conducted a two‐sample Mendelian randomization study (MR) study using publicly available GWAS data. Inverse variance weighted (IVW) analysis was the main MR analysis technique and was supplemented with other sensitivity analyses. Forty‐two bacterial genera were associated with COVID‐19 susceptibility, hospitalization, and severity in the IVW method. Among these gut microbiota, five gut microbiota (genus unknowngenus [id.1000005472], family unknownfamily [id.1000005471], genus Tyzzerella3, order MollicutesRF9.id.11579, and phylum Actinobacteria) were significantly associated with COVID‐19 hospitalization and severity. Three gut microbiota (class Negativicutes, order Selenomonadales, and class Actinobacteria) were significantly associated with COVID‐19 hospitalization and susceptibility, while two microbiota (class Negativicutes and order Selenomonadales) were significantly associated with COVID‐19 hospitalization and severity, and susceptibility. Sensitivity analysis did not detect any heterogeneity and horizontal pleiotropy. Our findings demonstrated that several microorganisms were causally linked to COVID‐19, and improved our understanding of the relationship between gut microbiota and COVID‐19 pathology.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.28784