Acute kidney injury in children with haematological malignancy: a territory-wide study

• Published in: Pediatric nephrology (Berlin, West) West), 2023-11, Vol.38 (11), p.3823-3833
• Main Authors: Lam, Suet Ying, Chan, Eugene Yu-hin, Cheng, Frankie Wai Tso, Ma, Alison Lap Tak, Ha, Shau Yin
• Format: Article
• Language: English
• Subjects: Acute lymphoblastic leukemia; Acute myeloid leukemia; Acute renal failure; Blood cancer; Blood diseases; Care and treatment; Chemotherapy; Children; Complications and side effects; Demographic aspects; Epidemiology; Hematology; Kidney diseases; Kidneys; Leukemia; Lymphatic leukemia; Lymphoma; Lysis; Malignancy; Medicine; Medicine & Public Health; Multivariate analysis; Nephrology; Original Article; Patient outcomes; Patients; Pediatrics; Remission; Risk factors; Septic shock; Urology; What’s new in AKI
• ISSN: 0931-041X; 1432-198X
• DOI: 10.1007/s00467-023-06010-z

Background In onco-nephrology, data on acute kidney injury (AKI) among children with haematological malignancies are scarce. Methods A retrospective cohort study of all patients in Hong Kong diagnosed with haematological malignancies from 2019 to 2021 before 18 years of age, was conducted to investigate the epidemiology, risk factors and clinical outcomes of AKI during the first year of treatment. AKI was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Results We included 130 children with haematological malignancy at median age of 9.4 years (IQR, 3.9–14.1). Of these patients, 55.4% were acute lymphoblastic leukemia (ALL), 26.9% were lymphoma and 17.7% were acute myeloid leukemia (AML). Thirty-five patients (26.9%) developed 41 AKI episodes during the first year of diagnosis, corresponding to 32 episodes per 100-patient-year. A total of 56.1% and 29.2% of the AKI episodes occurred during induction and consolidation chemotherapy respectively. Septic shock ( n  = 12, 29.2%) was the leading cause of AKI; 21 episodes (51.2%) were stage 3 AKI; 12 episodes (29.3%) were stage 2 AKI; and 6 patients required continuous kidney replacement therapies. Tumor lysis syndrome and impaired baseline kidney function were significantly associated with AKI on multivariate analysis ( P  = 0.01). History of AKI was associated with chemotherapy postponement (37.1% vs. 16.8%, P  = 0.01), worse 12-month patient survival (77.1% vs. 94.7%, log rank P  = 0.002) and lower disease remission rate at 12-month (68.6% vs. 88.4%, P  = 0.007), compared to patients without AKI. Conclusion AKI is a common complication during treatment of haematological malignancies which is associated with worse treatment outcomes. A regular and dedicated surveillance program for at-risk patients should be studied in children with haematological malignancies for prevention and early detection of AKI. Graphical abstract A higher resolution version of the Graphical abstract is available as Supplementary information