Relationship Between High Sensitivity C-reactive Protein to Albumin Ratio With Infarct-related Artery Patency in Patients With Non-ST-segment Elevation Myocardial Infarction

The C-reactive protein/albumin ratio (CAR) has recently emerged as a marker for poor prognosis or mortality in various patient groups. This study aimed to examine the relationship between serum CAR and infarct-related artery (IRA) patency in 700 consecutive non-ST-segment elevation myocardial infarc...

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Bibliographic Details
Published in:Angiology 2024-08, Vol.75 (7), p.682-688
Main Authors: Özkan, Can, Karayiğit, Orhan
Format: Article
Language:English
Subjects:
Aged
Biomarkers - blood
C-Reactive Protein - analysis
C-Reactive Protein - metabolism
Coronary Angiography
Coronary Vessels - diagnostic imaging
Coronary Vessels - physiopathology
Female
Humans
Male
Middle Aged
Non-ST Elevated Myocardial Infarction - blood
Non-ST Elevated Myocardial Infarction - physiopathology
Non-ST Elevated Myocardial Infarction - therapy
Percutaneous Coronary Intervention
Predictive Value of Tests
Prognosis
Retrospective Studies
Serum Albumin, Human - analysis
Vascular Patency
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Summary:The C-reactive protein/albumin ratio (CAR) has recently emerged as a marker for poor prognosis or mortality in various patient groups. This study aimed to examine the relationship between serum CAR and infarct-related artery (IRA) patency in 700 consecutive non-ST-segment elevation myocardial infarction (NSTEMI) patients prior to percutaneous coronary intervention. The study population was separated into 2 different groups according to preprocedural IRA patency as assessed by the degree of Thrombolysis in Myocardial Infarction (TIMI) flow. As a result, occluded IRA was defined as TIMI grade 0-1, while patent IRA was defined as TIMI grade 2-3. High CAR (Odds Ratio: 3.153 (1.249-8.022); P < .001) was found to be an independent predictor of occluded IRA. Additionally, CAR was positively correlated with the SYNTAX score, neutrophil/lymphocyte ratio, and platelet/lymphocyte ratio; CAR was negatively correlated with left ventricular ejection fraction. The highest cut-off value of CAR predicting occluded IRA was found to be .18 with 68.3% sensitivity and 67.9% specificity. The area under the curve for CAR was .744 (95% CI: .706-.781) after the receiver-operating characteristic curve assessment.
ISSN:0003-3197
1940-1574
1940-1574
DOI:10.1177/00033197231176983