Ventilatory function and oxygen delivery at high altitude in the Himalayas

This study aimed to evaluate changes in lung function assessed by spirometry and blood gas content in healthy high-altitude sojourners during a trek in the Himalayas. A group of 19 Italian adults (11 males and 8 females, mean age 43 ± 15 years, and BMI 24.2 ± 3.7 kg/m2) were evaluated as part of a M...

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Published in:Respiratory physiology & neurobiology 2023-08, Vol.314, p.104086-104086, Article 104086
Main Authors: Prosperi, Pierpaolo, Verratti, Vittore, Taverna, Alberto, Rua, Riccardo, Bonan, Sofia, Rapacchiale, Giorgia, Bondi, Danilo, Di Giulio, Camillo, Lorkowski, Jacek, Spacone, Antonella
Format: Article
Language:English
Subjects:
Adult
Altitude
Altitude hypoxia
Altitude Sickness
Arterial blood gas content
Female
Forced Expiratory Volume
Himalayas
Humans
Hypoxia
Male
Middle Aged
Oxygen
Pulse oximetry
Spirometry
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Summary:This study aimed to evaluate changes in lung function assessed by spirometry and blood gas content in healthy high-altitude sojourners during a trek in the Himalayas. A group of 19 Italian adults (11 males and 8 females, mean age 43 ± 15 years, and BMI 24.2 ± 3.7 kg/m2) were evaluated as part of a Mount Everest expedition in Nepal. Spirometry and arterial blood gas content were evaluated at baseline in Kathmandu (≈1400 m), at the Pyramid Laboratory - Observatory (peak altitude of ≈5000 m), and on return to Kathmandu 2–3 days after arrival at each site. All participants took 250 mg of acetazolamide per os once daily during the ascent. We found that arterial hemoglobin saturation, O2 and CO2 partial pressures, and the bicarbonate level all decreased (in all cases, p 
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2023.104086