Autoimmune Pancreatitis in Patients with Inflammatory Bowel Disease: A Real-World Multicentre Collaborative ECCO CONFER Study

• Published in: Journal of Crohn's and colitis 2023-11, Vol.17 (11), p.1791-1799
• Main Authors: Eder, Piotr, Verstock, Bram, Culver, Emma, Dragoni, Gabriele, Kredel, Lea Isabell, Wypych, Joanna, de Paredes, Ana Garcia Garcia, Kaniewska, Magdalena, Leibovitzh, Haim, Lobaton, Triana, Truyens, Marie, Oracz, Grzegorz, Ribaldone, Davide Giuseppe, Starzyńska, Teresa, Badaoui, Abdenor, Rahier, Jean-Francois, Bezzio, Cristina, Bossuyt, Peter, Falloon, Katherine, Pugliese, Daniela, Frakes Vozzo, Catherine, Jess, Tine, Larsen, Lone, Olesen, Søren Schou, Pal, Partha, Chaparro, María, Dror, Dikla, Ellul, Pierre, Gromny, Iga, Janiak, Maria, Maciejewska, Katarzyna, Peleg, Noam, Bar-Gil Shitrit, Ariella, Szwed, Łukasz, Talar-Wojnarowska, Renata, Snir, Yifat, Weisshof, Roni, Zittan, Eran, Miechowicz, Izabela, Goren, Idan
• Format: Article
• Language: English
• Subjects: Adult; Autoimmune Diseases - complications; Autoimmune Diseases - epidemiology; Autoimmune Pancreatitis - complications; Colitis, Ulcerative - complications; Colitis, Ulcerative - diagnosis; Colitis, Ulcerative - therapy; Crohn Disease - complications; Crohn Disease - diagnosis; Crohn Disease - epidemiology; Female; Humans; Inflammatory Bowel Diseases - complications; Inflammatory Bowel Diseases - diagnosis; Male; Middle Aged; Pancreatitis - epidemiology; Pancreatitis - etiology; Retrospective Studies; Young Adult
• ISSN: 1873-9946; 1876-4479
• DOI: 10.1093/ecco-jcc/jjad097

Abstract Background Autoimmune pancreatitis [AIP] is rarely associated with inflammatory bowel disease [IBD]. The long-term outcomes of AIP and IBD in patients with coexisting AIP–IBD and predictors of complicated AIP course have rarely been reported. Methods An ECCO COllaborative Network For Exceptionally Rare case reports project [ECCO-CONFER] collected cases of AIP diagnosed in patients with IBD. Complicated AIP was defined as a composite of endocrine and/or exocrine pancreatic insufficiency, and/or pancreatic cancer. We explored factors associated with complicated AIP in IBD. Results We included 96 patients [53% males, 79% ulcerative colitis, 72% type 2 AIP, age at AIP diagnosis 35 ± 16 years]. The majority of Crohn’s disease [CD] cases [78%] had colonic/ileocolonic involvement. In 59%, IBD preceded AIP diagnosis, whereas 18% were diagnosed simultaneously. Advanced therapy to control IBD was used in 61% and 17% underwent IBD-related surgery. In total, 82% of patients were treated with steroids for AIP, the majority of whom [91%] responded to a single course of treatment. During a mean follow-up of 7 years, AIP complications occurred in 25/96 [26%] individuals. In a multivariate model, older age at AIP diagnosis was associated with a complicated AIP course (odds ratio [OR] = 1.05, p = 0.008), whereas family history of IBD [OR = 0.1, p = 0.03], and CD diagnosis [OR = 0.2, p = 0.04] decreased the risk of AIP complications. No IBD- or AIP-related deaths occurred. Conclusions In this large international cohort of patients with concomitant AIP–IBD, most patients have type 2 AIP and colonic IBD. AIP course is relatively benign and long-term outcomes are favourable, but one-quarter develop pancreatic complications. Age, familial history of IBD, and CD may predict uncomplicated AIP course. Graphical Abstract Graphical Abstract