Repurposing of neprilysin inhibitor ‘sacubitrilat’ as an anti-cancer drug by modulating epigenetic and apoptotic regulators

Modifications in the epigenetic landscape have been considered a hallmark of cancer. Histone deacetylation is one of the crucial epigenetic modulations associated with the aggressive progression of various cancer subtypes. Herein, we have repurposed the neprilysin inhibitor sacubitrilat as a potent...

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Bibliographic Details
Published in:Scientific reports 2023-06, Vol.13 (1), p.9952-19, Article 9952
Main Authors: Kumbhar, Navanath, Nimal, Snehal, Patil, Deeksha, Kaiser, V. Florian, Haupt, Joachim, Gacche, Rajesh N.
Format: Article
Language:English
Subjects:
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Antineoplastic Agents - pharmacology
Antitumor activity
Antitumor agents
Apoptosis
Apoptosis Regulatory Proteins - metabolism
BAX protein
Breast cancer
Cancer
Cell cycle
Cell death
Cell Line, Tumor
Cell Proliferation
Clinical trials
Colorectal cancer
Colorectal carcinoma
Deacetylation
Drug Repositioning
Epigenesis, Genetic
Epigenetics
Flow cytometry
G1 phase
Histone deacetylase
Histones
Humanities and Social Sciences
Humans
Isoforms
Molecular Docking Simulation
multidisciplinary
Neprilysin
Neprilysin - antagonists & inhibitors
p53 Protein
Protein folding
Proteomics
Science
Science (multidisciplinary)
Transcriptomics
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