Clearance of intracellular bacterial infections by hyaluronic acid-based ROS responsive drug delivery micelles

Pathogenic bacteria residing inside cells could cause disruption of cellular metabolic balance. Therefore, basing on high oxidative stress response of the intracellular bacteria infected micro-environment, a novel amphipathic micelle (HATAD-TCS) was developed consisting of hyaluronic acid-derivative...

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Bibliographic Details
Published in:International journal of biological macromolecules 2023-08, Vol.245, p.125506-125506, Article 125506
Main Authors: Qiu, Yuanhao, Shang, Kun, Xu, Ningning, Chen, Peng, Gao, Huashan, Mu, Haibo, Feng, Wenpo, Duan, Jinyou
Format: Article
Language:English
Subjects:
Animals
Bacterial Infections
Cinnamaldehyde
Hyaluronic Acid
Intracellular bacterial infection
Mice
Micelles
Reactive Oxygen Species - metabolism
ROS-responsive
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Summary:Pathogenic bacteria residing inside cells could cause disruption of cellular metabolic balance. Therefore, basing on high oxidative stress response of the intracellular bacteria infected micro-environment, a novel amphipathic micelle (HATAD-TCS) was developed consisting of hyaluronic acid-derivative and reactive oxygen species (ROS) - responsive group and antibacterial agent triclosan (TCS). ROS-generating cinnamaldehyde (CA) was incorporated into ROS-cleavable linkages which are future linked to the 1-decylamine to form hydrophobicity. The cinnamaldehyde released did not just killed bacteria however, also maintained intracellular ROS levels. In this study, the HATAD-TCS micelles have been characterized by scanning electron microscopy (SEM) and dynamic light scattering (DLS). The HATAD-TCS micelles could release drug gradually upon exposure to endogenous ROS being caused by infected intracellular bacteria. Furthermore, the more promising therapeutic effect of the HATAD-TCS micelles was observed in a mouse pneumonia model. These results might highlight a ROS-responsive hyaluronic acid-based nanoparticle, which could effectively treat intracellular bacterial infections.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2023.125506