Crystal structures of Na+,K+‐ATPase reveal the mechanism that converts the K+‐bound form to Na+‐bound form and opens and closes the cytoplasmic gate

Na+,K+‐ATPase (NKA) plays a pivotal role in establishing electrochemical gradients for Na+ and K+ across the cell membrane by alternating between the E1 (showing high affinity for Na+ and low affinity for K+) and E2 (low affinity to Na+ and high affinity to K+) forms. Presented here are two crystal...

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Bibliographic Details
Published in:FEBS letters 2023-08, Vol.597 (15), p.1957-1976
Main Authors: Kanai, Ryuta, Vilsen, Bente, Cornelius, Flemming, Toyoshima, Chikashi
Format: Article
Language:English
Subjects:
Cell Membrane - metabolism
cryo‐electron microscopy
Cytoplasm - metabolism
Cytosol - metabolism
electrochemistry
Ions - metabolism
lipid bilayers
Na+,K+‐ATPase
occlusion
Potassium - metabolism
sodium pump
sodium-potassium-exchanging ATPase
Sodium-Potassium-Exchanging ATPase - chemistry
X‐ray crystallography
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