Sutton's Law

Kleiman and Hyde discuss the article The Nature of Prefrontal Cortical GABA Neuron Alterations in Schizophrenia: Markedly Lower Somatostatin and Parvalbumin Gene Expression Without Missing Neurons by Dienel et al. Using postmortem human brain to elucidate the molecular biology of brain disease is a...

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Bibliographic Details
Published in:The American journal of psychiatry 2023-07, Vol.180 (7), p.465-466
Main Authors: Kleinman, Joel E, Hyde, Thomas M
Format: Article
Language:English
Subjects:
Brain
Neurons
Parkinson's disease
Schizophrenia
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Summary:Kleiman and Hyde discuss the article The Nature of Prefrontal Cortical GABA Neuron Alterations in Schizophrenia: Markedly Lower Somatostatin and Parvalbumin Gene Expression Without Missing Neurons by Dienel et al. Using postmortem human brain to elucidate the molecular biology of brain disease is a strategy consistent with Sutton's Law. The work of Ehringer and Hornykiewicz, which found decreased dopamine in the striatum of postmortem brains of patients with Parkinson's disease, was a resounding demonstration of the wisdom of this strategy. It paved the way for the use of L-dopa, the metabolic precursor of dopamine, in the treatment of Parkinson' disease .
ISSN:0002-953X
1535-7228
DOI:10.1176/appi.ajp.20230403