Impaired lung function in multiple sclerosis: a single-center observational study in 371 persons

• Published in: Neurological sciences 2023-12, Vol.44 (12), p.4429-4439
• Main Authors: Murrieta-Álvarez, Iván, A. Fernández-Gutiérrez, José, A. Pérez, Carlos, León-Peña, Andrés A., Reyes-Cisneros, Óscar A., Benítez-Salazar, José M., Sánchez-Bonilla, Daniela, Olivares-Gazca, Juan C., Fernández-Lara, Danitza, Pérez-Padilla, Rogelio, Ruiz-Delgado, Guillermo J., Ruiz-Argüelles, Guillermo J.
• Format: Article
• Language: English
• Subjects: Central nervous system; Cognitive ability; Corpus callosum; Hippocampus; Lungs; Magnetic resonance imaging; Medicine; Medicine & Public Health; Multiple sclerosis; Neuroimaging; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Observational studies; Original Article; Psychiatry; Respiratory function
• ISSN: 1590-1874; 1590-3478
• DOI: 10.1007/s10072-023-06914-6

Introduction Abnormal lung function in people with multiple sclerosis (PwMS) could be considered as the result of muscle weakness or MS-specific structural central nervous system (CNS) abnormalities as a precipitant factor for the worsening of motor impairment or cognitive symptoms. Methods This is a cross-sectional observational study in PwMS. Forced spirometry was conducted, and normative metrics of forced vital capacity (FVC), forced expiratory volume in the first second (FEV 1 ), and the relation FEV1/FVC were calculated. Qualitative and quantitative brain magnetic resonance imaging (MRI) examinations were carried out. Results A total of 371 PwMS were included in the study. Of those, 196 (53%) had RRMS, 92 (25%) SPMS, and 83 (22%) PPMS. Low FVC and FEV 1 was present in 16 (8%), 16 (19%), and 23 (25%) of the patients in the RRMS, PPMS, and SPMS, respectively. PwMS with T2-FLAIR lesions involving the corpus callosum (CC) had a significantly higher frequency of abnormally low FVC and FEV 1 (OR 3.62; 95% CI 1.33–9.83; p = 0.012) than patients without lesions in that region. This association remained significant in the RRMS group (OR 10.1; 95% CI 1.3–67.8; p 0.031) when the model excluded PPMS and SPMS. According to our study, for every increase of 1 z score of FVC, we observed an increase of 0.25 cm 3 of hippocampal volume ( β 0.25; 95% CI 0.03–0.47; p 0.023) and 0.43 cm 3 of left hippocampus volume ( β 0.43; 95% CI 0.16–0.71; p 0.002). Conclusions We observed an incremental prevalence of abnormally low pulmonary function tests that parallels a sequence from more early relapsing courses to long-standing progressive courses (RRMS to PPMS or SPMS).