Fucoxanthin triggers ferroptosis in glioblastoma cells by stabilizing the transferrin receptor

Glioblastoma (GBM) is the most common and lethal tumor in the world, possessing high stemness, aggressiveness and resistance. Fucoxanthin is a bio-active compound extracted from seaweeds that shows anti-tumor effects to different types of tumors. Here, we show that fucoxanthin inhibits the survival...

Full description

Saved in:
Bibliographic Details
Published in:Medical oncology (Northwood, London, England) London, England), 2023-07, Vol.40 (8), p.230-230, Article 230
Main Authors: Zhu, Qin, Zhou, Yanqing, Wang, Haixia, Cao, Tao, Wang, Xinzhi, Liu, Rui, Wu, Hao, Lin, Binyan
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Apoptosis
Brain cancer
Cancer therapies
Cell Line, Tumor
Cells
Ferroptosis
Glioblastoma - metabolism
Hematology
Humans
Internal Medicine
Lipid peroxidation
Lipids
Medical research
Medicine
Medicine & Public Health
Nervous system
Oncology
Original Paper
Pathology
Reactive oxygen species
Receptors, Transferrin
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Glioblastoma (GBM) is the most common and lethal tumor in the world, possessing high stemness, aggressiveness and resistance. Fucoxanthin is a bio-active compound extracted from seaweeds that shows anti-tumor effects to different types of tumors. Here, we show that fucoxanthin inhibits the survival of GBM cells by triggering ferroptosis, a ferric ion and reactive oxygen species (ROS) dependent cell death and ferrostatin-1 could block it. Furthermore, we identified that fucoxanthin targets the transferrin receptor (TFRC). Fucoxanthin is able to block degradation and maintain high levels of TFRC, and similarly inhibits the growth of GBM xenografts in vivo, downregulates the expression of proliferating cell nuclear antigen (PCNA) and upregulates the levels of TFRC in tumor tissues. In conclusion, we demonstrate that fucoxanthin has a significant anti-GBM effect by triggering ferroptosis. Graphical abstract
ISSN:1559-131X
1357-0560
1559-131X
DOI:10.1007/s12032-023-02095-6