Selective Electroporation of Tumor Cells Under AC Radiofrequency Stimulation - A Numerical Study

Self-consistent evaluations of membrane electroporation along with local heating in single spherical cells arising from external AC radiofrequency electrical stimulation have been carried out. The present numerical study seeks to determine whether healthy and malignant cells exhibit separate electro...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 2024-01, Vol.PP (1), p.1-9
Main Authors: Baker, Cody, Milestone, William, Garner, Allen L., Joshi, R. P.
Format: Article
Language:English
Subjects:
Biomembranes
Burkitt's lymphoma
Cell electroporation
Conductivity
Electric fields
Electrical stimuli
Electroporation
Frequency ranges
Healthy and tumor cells
Heating systems
Lymphocytes B
Lymphocytes T
Lymphoma
Mathematical models
Radio frequency
RF frequency
Selectivity
Stimulation
Transmembrane voltage
Tumor cells
Tumors
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Summary:Self-consistent evaluations of membrane electroporation along with local heating in single spherical cells arising from external AC radiofrequency electrical stimulation have been carried out. The present numerical study seeks to determine whether healthy and malignant cells exhibit separate electroporative responses with regards to operating frequency. It is shown that cells of Burkitt's lymphoma would respond to frequencies >4.5 MHz, while normal B-cells would have negligible porative effects in that higher frequency range. Similarly, a frequency separation between the response of healthy T-cells and malignant species is predicted with a threshold of about 4 MHz for cancer cells. The present simulation technique is general and so would be able to ascertain the beneficial frequency range for different cell types. The demonstration of higher frequencies to induce poration in malignant cells, while having minimal affecting healthy ones, suggests the possibility of selective electrical targeting for tumor treatments and protocols. It also opens the doorway for tabulating selectivity enhancement regimes as a guide for parameter selection towards more effective treatments while minimizing deleterious effects on healthy cells and tissues.
ISSN:0018-9294
1558-2531
DOI:10.1109/TBME.2023.3293278