Systems-level profiling of early peripheral host-response landscape variations across COVID-19 severity states in an Indian cohort

Host immune response to COVID-19 plays a significant role in regulating disease severity. Although big data analysis has provided significant insights into the host biology of COVID-19 across the world, very few such studies have been performed in the Indian population. This study utilizes a transcr...

Full description

Saved in:
Bibliographic Details
Published in:Genes and immunity 2023-08, Vol.24 (4), p.183-193
Main Authors: Banerjee, Ushashi, Chunchanur, Sneha, R, Ambica, Balaji, Kithiganahalli Narayanaswamy, Singh, Amit, Chakravortty, Dipshikha, Chandra, Nagasuma
Format: Article
Language:English
Subjects:
38
38/39
38/91
631/208/199
631/250/254
Biomedical and Life Sciences
Biomedicine
Cancer Research
COVID-19
ESR1 protein
Gene Expression
Human Genetics
Immune response
Immunology
Interferon regulatory factor 7
Phenotypes
Population studies
Transcription factors
Transcriptomes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Host immune response to COVID-19 plays a significant role in regulating disease severity. Although big data analysis has provided significant insights into the host biology of COVID-19 across the world, very few such studies have been performed in the Indian population. This study utilizes a transcriptome-integrated network analysis approach to compare the immune responses between asymptomatic or mild and moderate-severe COVID-19 patients in an Indian cohort. An immune suppression phenotype is observed in the early stages of moderate-severe COVID-19 manifestation. A number of pathways are identified that play crucial roles in the host control of the disease such as the type I interferon response and classical complement pathway which show different activity levels across the severity spectrum. This study also identifies two transcription factors, IRF7 and ESR1, to be important in regulating the severity of COVID-19. Overall this study provides a deep understanding of the peripheral immune landscape in the COVID-19 severity spectrum in the Indian genetic background and opens up future research avenues to compare immune responses across global populations.
ISSN:1476-5470
1466-4879
1476-5470
DOI:10.1038/s41435-023-00210-1