New weapons against the disease vector Aedes aegypti: From natural products to nanoparticles

• Published in: International journal of pharmaceutics 2023-08, Vol.643, p.123221-123221, Article 123221
• Main Authors: Rodrigues dos Santos, Daiane, Lopes Chaves, Luíse, Couto Pires, Vinícius, Soares Rodrigues, Júlia, Alves Siqueira de Assunção, Matheus, Bezerra Faierstein, Gabriel, Gomes Barbosa Neto, Adauto, de Souza Rebouças, Juliana, Christine de Magalhães Cabral Albuquerque, Elaine, Alexandre Beisl Vieira de Melo, Silvio, Costa Gaspar, Marisa, Maria Rodrigues Barbosa, Rosângela, Elga Medeiros Braga, Mara, Cipriano de Sousa, Hermínio, Rocha Formiga, Fabio
• Format: Article
• Language: English
• Subjects: Aedes aegypti; Arboviral diseases; Nanotechnology; Plant-based materials; Vector control
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2023.123221

[Display omitted] Despite the global burden of viral diseases transmitted by Aedes aegypti, there is a lack of effective means of prevention and treatment. Strategies for vector control include chemical and biological approaches such as organophosphates and Bacillus thuringiensis var. israelensis (Bti), among others. However, important concerns are associated, such as resistance in mosquito larvae and deleterious effects on non-target organisms. In this scenario, novel approaches against A. aegypti have been investigated, including natural products (e.g. vegetable oil and extracts) and nanostructured systems. This review focuses on potential strategies for fighting A. aegypti, highlighting plant-based materials and nanomaterials able to induce toxic effects on egg, larva, pupa and adult mosquitoes. Issues including aspects of conventional vector control strategies are presented, and finally new insights on development of eco-friendly nanoformulations against A. aegypti are discussed.