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The Role of Methylation of a Group of microRNA Genes in the Pathogenesis of Metastatic Renal Cell Carcinoma
The role of methylation of 9 miRNA genes in the pathogenesis of metastatic clear cell renal cell carcinoma was determined by quantitative methylation-specific PCR (MS-PCR). For 5 genes ( MIR125B-1 , MIR137 , MIR193A , MIR34B/C , and MIR375 ), a significant correlation of high methylation level with...
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| Published in: | Bulletin of experimental biology and medicine 2023-06, Vol.175 (2), p.249-253 |
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| container_end_page | 253 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Ivanova, N. A. Burdennyi, A. M. Lukina, S. S. Filippova, E. A. Pronina, I. V. Karpukhin, A. V. Matveev, V. B. Kazubskaya, T. P. Loginov, V. I. Braga, E. A. Kushlinskii, N. E. |
| description | The role of methylation of 9 miRNA genes in the pathogenesis of metastatic clear cell renal cell carcinoma was determined by quantitative methylation-specific PCR (MS-PCR). For 5 genes (
MIR125B-1
,
MIR137
,
MIR193A
,
MIR34B/C
, and
MIR375
), a significant correlation of high methylation level with late (III-IV) stages, large size (T3+T4) of the tumor, and metastasis to lymph nodes and/or distant organs was revealed. For another group of genes (
MIR125B-1
,
MIR1258
,
MIR193A
,
MIR34B/C
, and
MIR375
), a statistically significant correlation of high methylation level with loss of differentiation in the tumor (G3-G4) was found, and the opposite pattern was found for
MIR203A
. A total of 7 microRNA genes (
MIR125B-1
,
MIR1258
,
MIR137
,
MIR193A
,
MIR203A
,
MIR34B/C
, and
MIR375
) were identified, the methylation of which is associated with the progression of metastatic clear cell renal cell carcinoma. For 6 of them (except
MIR34B/C
) these data were obtained for the first time. Thus, new factors of the development and progression of clear cell renal cell carcinoma were identified as potential biomarkers for the early diagnosis and prognosis of metastatic clear cell renal cell carcinoma. |
| doi_str_mv | 10.1007/s10517-023-05844-9 |
| format | article |
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MIR125B-1
,
MIR137
,
MIR193A
,
MIR34B/C
, and
MIR375
), a significant correlation of high methylation level with late (III-IV) stages, large size (T3+T4) of the tumor, and metastasis to lymph nodes and/or distant organs was revealed. For another group of genes (
MIR125B-1
,
MIR1258
,
MIR193A
,
MIR34B/C
, and
MIR375
), a statistically significant correlation of high methylation level with loss of differentiation in the tumor (G3-G4) was found, and the opposite pattern was found for
MIR203A
. A total of 7 microRNA genes (
MIR125B-1
,
MIR1258
,
MIR137
,
MIR193A
,
MIR203A
,
MIR34B/C
, and
MIR375
) were identified, the methylation of which is associated with the progression of metastatic clear cell renal cell carcinoma. For 6 of them (except
MIR34B/C
) these data were obtained for the first time. Thus, new factors of the development and progression of clear cell renal cell carcinoma were identified as potential biomarkers for the early diagnosis and prognosis of metastatic clear cell renal cell carcinoma.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-023-05844-9</identifier><identifier>PMID: 37466853</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Cancer ; Carcinoma, Renal cell ; Cell Biology ; Clear cell-type renal cell carcinoma ; Development and progression ; DNA methylation ; Genes ; Genetic aspects ; Internal Medicine ; Kidney cancer ; Laboratory Medicine ; Lymph nodes ; Metastases ; Metastasis ; Methylation ; MicroRNA ; MicroRNAs ; miRNA ; Oncology ; Pathogenesis ; Pathology ; Statistical analysis ; Tumors</subject><ispartof>Bulletin of experimental biology and medicine, 2023-06, Vol.175 (2), p.249-253</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>COPYRIGHT 2023 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c424t-b1b22440e19f19f57158c5bd38fa641c885c692a36846c1ae0da1b9281dcd0183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37466853$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ivanova, N. A.</creatorcontrib><creatorcontrib>Burdennyi, A. M.</creatorcontrib><creatorcontrib>Lukina, S. S.</creatorcontrib><creatorcontrib>Filippova, E. A.</creatorcontrib><creatorcontrib>Pronina, I. V.</creatorcontrib><creatorcontrib>Karpukhin, A. V.</creatorcontrib><creatorcontrib>Matveev, V. B.</creatorcontrib><creatorcontrib>Kazubskaya, T. P.</creatorcontrib><creatorcontrib>Loginov, V. I.</creatorcontrib><creatorcontrib>Braga, E. A.</creatorcontrib><creatorcontrib>Kushlinskii, N. E.</creatorcontrib><title>The Role of Methylation of a Group of microRNA Genes in the Pathogenesis of Metastatic Renal Cell Carcinoma</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>The role of methylation of 9 miRNA genes in the pathogenesis of metastatic clear cell renal cell carcinoma was determined by quantitative methylation-specific PCR (MS-PCR). For 5 genes (
MIR125B-1
,
MIR137
,
MIR193A
,
MIR34B/C
, and
MIR375
), a significant correlation of high methylation level with late (III-IV) stages, large size (T3+T4) of the tumor, and metastasis to lymph nodes and/or distant organs was revealed. For another group of genes (
MIR125B-1
,
MIR1258
,
MIR193A
,
MIR34B/C
, and
MIR375
), a statistically significant correlation of high methylation level with loss of differentiation in the tumor (G3-G4) was found, and the opposite pattern was found for
MIR203A
. A total of 7 microRNA genes (
MIR125B-1
,
MIR1258
,
MIR137
,
MIR193A
,
MIR203A
,
MIR34B/C
, and
MIR375
) were identified, the methylation of which is associated with the progression of metastatic clear cell renal cell carcinoma. For 6 of them (except
MIR34B/C
) these data were obtained for the first time. Thus, new factors of the development and progression of clear cell renal cell carcinoma were identified as potential biomarkers for the early diagnosis and prognosis of metastatic clear cell renal cell carcinoma.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer</subject><subject>Carcinoma, Renal cell</subject><subject>Cell Biology</subject><subject>Clear cell-type renal cell carcinoma</subject><subject>Development and progression</subject><subject>DNA methylation</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Internal Medicine</subject><subject>Kidney cancer</subject><subject>Laboratory Medicine</subject><subject>Lymph nodes</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Methylation</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>miRNA</subject><subject>Oncology</subject><subject>Pathogenesis</subject><subject>Pathology</subject><subject>Statistical analysis</subject><subject>Tumors</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kk1v1DAQhi0EokvhD3BAlpAQlxR_2zmuVrBUKh9albPlOJNNShIvdnLov8dht5QihGzZnvHzjjyeQeglJReUEP0uUSKpLgjjBZFGiKJ8hFZUal4YxuhjtCKZKoQx5gw9S-lmMYmiT9EZ10IpI_kKfb9uAe9CDzg0-BNM7W3vpi6Mi-nwNob5sByHzsew-7zGWxgh4W7EU9Z9dVMb9ounSye9S1PWe7yD0fV4A31eXPTdGAb3HD1pXJ_gxWk_R98-vL_efCyuvmwvN-urwgsmpqKiFWNCEKBlk6fUVBovq5qbxilBvTHSq5I5roxQnjogtaNVyQytfU2o4efo7THuIYYfM6TJDl3y-SluhDAnywwvNTeKi4y-_gu9CXPMT18owVRZSqHvqb3rwXZjE6bo_BLUrrWSQhKtZaYu_kHlUUP-vjBC02X_A8GbPwQtuH5qU-jn5f_TQ5AdwVyElCI09hC7wcVbS4ldWsEeW8HmVrC_WsGWWfTqlNpcDVD_ltzVPgP8CKR8Ne4h3uf-n7A_AWDAulA</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Ivanova, N. A.</creator><creator>Burdennyi, A. M.</creator><creator>Lukina, S. S.</creator><creator>Filippova, E. A.</creator><creator>Pronina, I. V.</creator><creator>Karpukhin, A. V.</creator><creator>Matveev, V. B.</creator><creator>Kazubskaya, T. P.</creator><creator>Loginov, V. I.</creator><creator>Braga, E. A.</creator><creator>Kushlinskii, N. E.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20230601</creationdate><title>The Role of Methylation of a Group of microRNA Genes in the Pathogenesis of Metastatic Renal Cell Carcinoma</title><author>Ivanova, N. A. ; Burdennyi, A. M. ; Lukina, S. S. ; Filippova, E. A. ; Pronina, I. V. ; Karpukhin, A. V. ; Matveev, V. B. ; Kazubskaya, T. P. ; Loginov, V. I. ; Braga, E. A. ; Kushlinskii, N. 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A.</creatorcontrib><creatorcontrib>Burdennyi, A. M.</creatorcontrib><creatorcontrib>Lukina, S. S.</creatorcontrib><creatorcontrib>Filippova, E. A.</creatorcontrib><creatorcontrib>Pronina, I. V.</creatorcontrib><creatorcontrib>Karpukhin, A. V.</creatorcontrib><creatorcontrib>Matveev, V. B.</creatorcontrib><creatorcontrib>Kazubskaya, T. P.</creatorcontrib><creatorcontrib>Loginov, V. I.</creatorcontrib><creatorcontrib>Braga, E. A.</creatorcontrib><creatorcontrib>Kushlinskii, N. E.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ivanova, N. A.</au><au>Burdennyi, A. M.</au><au>Lukina, S. S.</au><au>Filippova, E. A.</au><au>Pronina, I. V.</au><au>Karpukhin, A. V.</au><au>Matveev, V. B.</au><au>Kazubskaya, T. P.</au><au>Loginov, V. I.</au><au>Braga, E. A.</au><au>Kushlinskii, N. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Methylation of a Group of microRNA Genes in the Pathogenesis of Metastatic Renal Cell Carcinoma</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2023-06-01</date><risdate>2023</risdate><volume>175</volume><issue>2</issue><spage>249</spage><epage>253</epage><pages>249-253</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>The role of methylation of 9 miRNA genes in the pathogenesis of metastatic clear cell renal cell carcinoma was determined by quantitative methylation-specific PCR (MS-PCR). For 5 genes (
MIR125B-1
,
MIR137
,
MIR193A
,
MIR34B/C
, and
MIR375
), a significant correlation of high methylation level with late (III-IV) stages, large size (T3+T4) of the tumor, and metastasis to lymph nodes and/or distant organs was revealed. For another group of genes (
MIR125B-1
,
MIR1258
,
MIR193A
,
MIR34B/C
, and
MIR375
), a statistically significant correlation of high methylation level with loss of differentiation in the tumor (G3-G4) was found, and the opposite pattern was found for
MIR203A
. A total of 7 microRNA genes (
MIR125B-1
,
MIR1258
,
MIR137
,
MIR193A
,
MIR203A
,
MIR34B/C
, and
MIR375
) were identified, the methylation of which is associated with the progression of metastatic clear cell renal cell carcinoma. For 6 of them (except
MIR34B/C
) these data were obtained for the first time. Thus, new factors of the development and progression of clear cell renal cell carcinoma were identified as potential biomarkers for the early diagnosis and prognosis of metastatic clear cell renal cell carcinoma.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>37466853</pmid><doi>10.1007/s10517-023-05844-9</doi><tpages>5</tpages></addata></record> |
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| subjects | Biomedical and Life Sciences Biomedicine Cancer Carcinoma, Renal cell Cell Biology Clear cell-type renal cell carcinoma Development and progression DNA methylation Genes Genetic aspects Internal Medicine Kidney cancer Laboratory Medicine Lymph nodes Metastases Metastasis Methylation MicroRNA MicroRNAs miRNA Oncology Pathogenesis Pathology Statistical analysis Tumors |
| title | The Role of Methylation of a Group of microRNA Genes in the Pathogenesis of Metastatic Renal Cell Carcinoma |
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