Pregnancy and placental outcomes according to maternal BMI in women with preeclampsia: a retrospective cohort study

Purpose Obesity and preeclampsia share similar patho-mechanisms and can both affect placental pathology. We aimed to investigate pregnancy outcomes in correlation with placental pathology among pregnancies complicated by preeclampsia in three different maternal body mass index (BMI, kg/m 2 ) groups....

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Published in:Archives of gynecology and obstetrics 2024-06, Vol.309 (6), p.2521-2528
Main Authors: Barber, Elad, Ram, Maya, Mor, Liat, Ganor Paz, Yael, Shmueli, Anat, Bornstein, Sandy, Barda, Giulia, Schreiber, Letizia, Weiner, Eran, Levy, Michal
Format: Article
Language:English
Subjects:
Adult
Birth Weight
Body Mass Index
Cohort analysis
Cohort Studies
Endocrinology
Female
Gynecology
Human Genetics
Humans
Infant, Newborn
Maternal-Fetal Medicine
Medicine
Medicine & Public Health
Obesity - complications
Obstetrics/Perinatology/Midwifery
Pathology
Placenta - blood supply
Placenta - pathology
Pre-Eclampsia - epidemiology
Preeclampsia
Pregnancy
Pregnancy Outcome - epidemiology
Retrospective Studies
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Summary:Purpose Obesity and preeclampsia share similar patho-mechanisms and can both affect placental pathology. We aimed to investigate pregnancy outcomes in correlation with placental pathology among pregnancies complicated by preeclampsia in three different maternal body mass index (BMI, kg/m 2 ) groups. Methods In this retrospective cohort study, medical and pathological records of patients with preeclampsia and a singleton pregnancy delivered between 2008 and 2021 at a single tertiary medical center were reviewed. Study population was divided into three BMI groups: BMI  28.0 kg/m 2 (high BMI group). Data regarding maternal characteristics, neonatal outcomes, and placental histopathological lesions were compared. Results The study groups included a total of 295 patients diagnosed with preeclampsia—98, 99, and 98 in the low, middle-range, and high BMI groups respectively. Neonatal birth weight was significantly decreased in the low maternal BMI group compared to both middle and high BMI groups ( p  = 0.04) with a similar trend seen in placental weight ( p  = 0.03). Villous changes related to maternal malperfusion were more prevalent in the low and high BMI groups compared to middle-range BMI group ( p  
ISSN:1432-0711
0932-0067
1432-0711
DOI:10.1007/s00404-023-07148-9