Identification of peptides presented through the MHC-II of dendritic cells stimulated with Mycobacterium avium

Mycobacterium avium (M. avium) represents a species of concern, because of its ability to modulate the host’s innate immune response, and therefore influence trajectory of adaptative immunity. Since eradicative response against mycobacteria, and M. tuberculosis/M. avium, relies on peptides actively...

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Published in:Immunobiology (1979) 2023-07, Vol.228 (4), p.152416-152416, Article 152416
Main Authors: Arredondo-Hernández, René, Schcolnik-Cabrera, Alejandro, Orduña, Patricia, Juárez-López, Daniel, Varela-Salinas, Tania, López-Vidal, Yolanda
Format: Article
Language:English
Subjects:
Dendritic cells
MHC-II
Mycobacterium avium
Peptides
Semi-mature phenotype
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Summary:Mycobacterium avium (M. avium) represents a species of concern, because of its ability to modulate the host’s innate immune response, and therefore influence trajectory of adaptative immunity. Since eradicative response against mycobacteria, and M. tuberculosis/M. avium, relies on peptides actively presented on a Major Histocompatibility complex-II (MHC-II) context, we assessed paradoxical stimulation of Dendritic Cell resulting on immature immunophenotype characterized by membrane minor increase of MHC-II and CD40 despite of high expression of the pro-inflammatory tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in supernatants. Identification of M. avium leucine rich peptides forming short α-helices shutting down Type 1T helper (Th1), contribute to the understanding of immune evasion of an increasingly prevalent pathogen, and may provide a basis for future immunotherapy to infectious and non-infectious disease.
ISSN:0171-2985
1878-3279
DOI:10.1016/j.imbio.2023.152416