Ru(phen)3 Cl2 -Catalyzed Chlorotrifluoromethylation of Unactivated Alkenes

A novel Ru(phen)3 Cl2 -catalyzed free-radical chlorotrifluoromethylation reaction of unactivated olefins was investigated. Substituted 8-aminoquinoline-derived inert enamides were reacted with the Togni regent to afford a broad range of Cl-containing trifluoromethyl derivatives in good yields. The r...

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Published in:ChemistryOpen (Weinheim) 2023-07, Vol.12 (7), p.e202300068
Main Authors: Su, Wenhao, Cui, Jing, Zeng, Runsheng
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description A novel Ru(phen)3 Cl2 -catalyzed free-radical chlorotrifluoromethylation reaction of unactivated olefins was investigated. Substituted 8-aminoquinoline-derived inert enamides were reacted with the Togni regent to afford a broad range of Cl-containing trifluoromethyl derivatives in good yields. The reaction proceeded at 90 °C and experimental result shows that the chlorine source of the products originated from LiCl.A novel Ru(phen)3 Cl2 -catalyzed free-radical chlorotrifluoromethylation reaction of unactivated olefins was investigated. Substituted 8-aminoquinoline-derived inert enamides were reacted with the Togni regent to afford a broad range of Cl-containing trifluoromethyl derivatives in good yields. The reaction proceeded at 90 °C and experimental result shows that the chlorine source of the products originated from LiCl.
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title Ru(phen)3 Cl2 -Catalyzed Chlorotrifluoromethylation of Unactivated Alkenes
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