Angiogenic imbalance in maternal and cord blood is associated with neonatal birth weight and head circumference in pregnancies with major fetal congenital heart defect

ABSTRACT Objectives To ascertain whether abnormalities in neonatal head circumference and/or body weight are associated with levels of angiogenic/antiangiogenic factors in the maternal and cord blood of pregnancies with a congenital heart defect (CHD) and to assess whether the specific type of CHD i...

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Bibliographic Details
Published in:Ultrasound in obstetrics & gynecology 2024-02, Vol.63 (2), p.214-221
Main Authors: Sánchez, O., Ribera, I., Ruiz, A., Eixarch, E., Antolín, E., Cruz‐Lemini, M., Dominguez, C., Arévalo, S., Ferrer, Q., Rodríguez‐Sureda, V., Crispi, F., Llurba, E.
Format: Article
Language:English
Subjects:
Abnormalities
Angiogenesis
Antiangiogenics
Biomarkers
Birth weight
Blood
Body measurements
Body weight
Childbirth & labor
Circumferences
congenital heart defect
Cord blood
Defects
Endoglin
Fetuses
Growth factors
Gynecology
Head
Heart
Kinases
maternal blood
neonatal cephalic biometry
Neonates
Newborn babies
Obstetrics
Placenta growth factor
placental growth factor
PlGF
Pregnancy
sFlt‐1
soluble fms‐like tyrosine kinase‐1
Standard error
Tyrosine
Ventricle
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Summary:ABSTRACT Objectives To ascertain whether abnormalities in neonatal head circumference and/or body weight are associated with levels of angiogenic/antiangiogenic factors in the maternal and cord blood of pregnancies with a congenital heart defect (CHD) and to assess whether the specific type of CHD influences this association. Methods This was a multicenter case–control study of women carrying a fetus with major CHD. Recruitment was carried out between June 2010 and July 2018 at four tertiary care hospitals in Spain. Maternal venous blood was drawn at study inclusion and at delivery. Cord blood samples were obtained at birth when possible. Placental growth factor (PlGF), soluble fms‐like tyrosine kinase‐1 (sFlt‐1) and soluble endoglin (sEng) were measured in maternal and cord blood. Biomarker concentrations in the maternal blood were expressed as multiples of the median (MoM). Results PlGF, sFlt‐1 and sEng levels were measured in the maternal blood in 237 cases with CHD and 260 healthy controls, and in the cord blood in 150 cases and 56 controls. Compared with controls, median PlGF MoM in maternal blood was significantly lower in the CHD group (0.959 vs 1.022; P 
ISSN:0960-7692
1469-0705
DOI:10.1002/uog.27441