Periprosthetic Joint Infections of the Knee Lastingly Impact the Bone Homeostasis

After periprosthetic joint infection (PJI)-dependent revision surgery, a significantly elevated number of patients suffer from prosthesis failure due to aseptic loosening and require additional revision surgery despite clearance of the initial infection. The mechanisms underlying this pathology are...

Full description

Saved in:
Bibliographic Details
Published in:Journal of bone and mineral research 2023-10, Vol.38 (10), p.1472-1479
Main Authors: Bandick, Evgeniya, Biedermann, Lara, Ren, Yi, Donner, Stefanie, Thiele, Mario, Korus, Gabriela, Tsitsilonis, Serafeim, Müller, Michael, Duda, Georg, Perka, Carsten, Kienzle, Arne
Format: Article
Language:English
Subjects:
Acid phosphatase (tartrate-resistant)
Bone composition
Bone implants
Bone mineral density
Bone surgery
Bone turnover
Cbfa-1 protein
Genetic markers
Homeostasis
Joint diseases
Osteocalcin
Osteoclastogenesis
Osteoclasts
Osteopontin
Patients
Prostheses
Surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:After periprosthetic joint infection (PJI)-dependent revision surgery, a significantly elevated number of patients suffer from prosthesis failure due to aseptic loosening and require additional revision surgery despite clearance of the initial infection. The mechanisms underlying this pathology are not well understood, as it has been assumed that the bone stock recovers after revision surgery. Despite clinical evidence suggesting decreased osteogenic potential in PJI, understanding of the underlying biology remains limited. In this study, we investigated the impact of PJI on bone homeostasis in a two-stage exchange approach at explantation and reimplantation. 64 human tibial and femoral specimens (20 control, 20 PJI septic explantation, and 24 PJI prosthesis reimplantation samples) were analyzed for their bone microstructure, cellular composition, and expression of relevant genetic markers. Samples were analyzed using X-ray microtomography, Alcian blue and TRAP staining, and RT-qPCR. In patients with PJI, bone volume (BV/TV; 0.173 ± 0.026; p 
ISSN:0884-0431
1523-4681
DOI:10.1002/jbmr.4892