Palbociclib in combination with chemotherapy in pediatric and young adult patients with relapsed/refractory acute lymphoblastic leukemia and lymphoma: A Children's Oncology Group study (AINV18P1)

• Published in: Pediatric blood & cancer 2023-11, Vol.70 (11), p.e30609-e30609
• Main Authors: Raetz, Elizabeth A, Teachey, David T, Minard, Charles, Liu, Xiaowei, Norris, Robin E, Denic, Kristina Z, Reid, Joel, Evensen, Nikki A, Gore, Lia, Fox, Elizabeth, Loh, Mignon L, Weigel, Brenda J, Carroll, William L
• Format: Article
• Language: English
• Subjects: Acute lymphoblastic leukemia; Cell cycle; Chemotherapy; Children; Children & youth; Cyclin D; Cyclin-dependent kinase 4; Leukemia; Lymphatic leukemia; Lymphoma; Oncology; Oral administration; Pediatrics; Pharmacokinetics; Toxicity; Young adults
• ISSN: 1545-5009; 1545-5017
• DOI: 10.1002/pbc.30609

Cyclin D has been shown to play an essential role in acute lymphoblastic leukemia (ALL) initiation and progression, providing rationale for targeting the CDK4/6-cyclin D complex that regulates cell cycle progression. The Children's Oncology Group AINV18P1 phase 1 trial evaluated the CDK4/6 inhibitor, palbociclib, in combination with standard four-drug re-induction chemotherapy in children and young adults with relapsed/refractory B- and T-cell lymphoblastic leukemia (ALL) and lymphoma. Palbociclib (50 mg/m /dose) was administered orally once daily for 21 consecutive days, first as a single agent (Days 1-3) and subsequently combined with re-induction chemotherapy. This two-part study was designed to determine the maximum tolerated dose (MTD) or recommended phase 2 dose (RP2D), followed by an expansion pharmacokinetic cohort. Twelve heavily pretreated patients enrolled, all of whom were evaluable for toxicity. One dose-limiting hematologic toxicity (DLT) occurred at the starting dose of 50 mg/m /dose orally for 21 days. No additional DLTs were observed in the dose determination or pharmacokinetic expansion cohorts, and overall rates of grade 3/4 nonhematologic toxicities were comparable to those observed with the chemotherapy platform alone. Five complete responses were observed, two among four patients with T-ALL and three among seven patients with B-ALL. Pharmacokinetic studies showed similar profiles with both liquid and capsule formulations of palbociclib. Palbociclib in combination with re-induction chemotherapy was well tolerated with a RP2D of 50 mg/m /day for 21 days. Complete responses were observed among heavily pretreated patients.