Tranexamic acid administered intraarticularly to the knee is safer for the articular cartilage and anterior cruciate ligament compared to intravenous administration: Histological analysis of an experimental rat model

In this study, the effects of tranexamic acid (TXA) on the knee’s articular cartilage, anterior cruciate ligament (ACL), and joint capsule were assessed histologically. There were 15 rats in each of the 3 groups, totaling 45 rats. Intraarticular (IA) saline injections were applied for the first grou...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 2024-02, Vol.397 (2), p.1045-1051
Main Authors: Çağlar, Ceyhun, Akçaalan, Serhat, Akçaalan, Yasemin, Akcan, Gülben, Tufan, Ahmet Cevik, Akkaya, Mustafa, Doğan, Metin
Format: Article
Language:English
Subjects:
Administration, Intravenous
Animals
Anterior Cruciate Ligament
Anterior Cruciate Ligament Injuries - drug therapy
Anterior Cruciate Ligament Injuries - pathology
Biomedical and Life Sciences
Biomedicine
Cartilage
Cartilage diseases
Cartilage, Articular
Femur
Intravenous administration
Knee
Knee Joint - pathology
Neurosciences
Pharmacology/Toxicology
Rats
Tranexamic Acid - pharmacology
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Summary:In this study, the effects of tranexamic acid (TXA) on the knee’s articular cartilage, anterior cruciate ligament (ACL), and joint capsule were assessed histologically. There were 15 rats in each of the 3 groups, totaling 45 rats. Intraarticular (IA) saline injections were applied for the first group, IA TXA injections for the second group, and intravenous (IV) TXA injections for the third group. Using samples taken from the knee joint 3 weeks later, the medial/lateral femoral condyle and medial/lateral tibial plateau articular cartilages were evaluated with Osteoarthritis Research Society International (OARSI) scoring, while ACL diameter and joint capsule thickness were analyzed histologically. In comparisons of OARSI scores for the medial/lateral femoral condyle and medial/lateral tibial plateau cartilage regions, the scores obtained for the IV TXA group were significantly higher than those of the IA saline group ( P  
ISSN:0028-1298
1432-1912
DOI:10.1007/s00210-023-02666-4