GIPR/GLP-1R dual agonist therapies for diabetes and weight loss—chemistry, physiology, and clinical applications

The incretin system is an essential metabolic axis that regulates postprandial metabolism. The two incretin peptides that enable this effect are the glucose-dependent insulinotropic polypeptide (GIP) and the glucagon-like peptide 1 (GLP-1), which have cognate receptors (GIPR and GLP-1R) on islet β c...

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Bibliographic Details
Published in:Cell metabolism 2023-09, Vol.35 (9), p.1519-1529
Main Authors: Campbell, Jonathan E., Müller, Timo D., Finan, Brian, DiMarchi, Richard D., Tschöp, Matthias H., D’Alessio, David A.
Format: Article
Language:English
Subjects:
Body Weight
Diabetes Mellitus - drug therapy
Humans
Hyperglycemia
Incretins - therapeutic use
Receptors, G-Protein-Coupled
Weight Loss
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