Association Between Non-alcoholic Fatty Liver Disease and Heavy Metal Exposure: a Systematic Review

Non-alcoholic fatty liver disease (NAFLD) is a debilitating disease with adverse effects including cirrhosis and hepatocellular carcinoma. Heavy metals can cause severe dysfunction in different body organs including the liver. This review offers the study regarding the positive or negative associati...

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Bibliographic Details
Published in:Biological trace element research 2023-12, Vol.201 (12), p.5607-5615
Main Authors: Sadighara, Parisa, Abedini, Amir Hossein, Irshad, Namra, Ghazi-Khansari, Mahmoud, Esrafili, Ali, Yousefi, Mahmood
Format: Article
Language:English
Subjects:
Alcohols
Arsenic
Biochemistry
Biomedical and Life Sciences
Biotechnology
Body organs
Cadmium
Chromium
Cirrhosis
copper
Fatty liver
Heavy metals
Hepatocellular carcinoma
hepatoma
Iron
Laboratory methods
Lead
Life Sciences
Liver
Liver diseases
Magnetic resonance imaging
magnetism
Mercury
Mercury (metal)
Neoplasms
Nickel
Nutrition
Oncology
Reviews
Systematic review
Thallium
Zinc
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Summary:Non-alcoholic fatty liver disease (NAFLD) is a debilitating disease with adverse effects including cirrhosis and hepatocellular carcinoma. Heavy metals can cause severe dysfunction in different body organs including the liver. This review offers the study regarding the positive or negative association between heavy metals exposure and non-alcoholic fatty liver disease. The method used in this study is a systematic review based on searching in the PubMed, Scopus, and Science direct databases with the keywords of fatty liver, non-alcohol fatty liver, heavy metal, mercury, cadmium, arsenic, chromium, thallium, lead, iron, zinc, and nickel. There were 2200 articles searched in databases, and after assessment, 28 articles were selected. Positive association is established between arsenic, cadmium, iron, lead, mercury, and fatty liver disease. A negative relationship is found between zinc, copper, and progressive fatty liver disease. Furthermore, laboratory methods for NAFLD diagnosis were examined according to the obtained manuscripts. Among the different diagnostic methods, magnetic resonance imaging (MRI) is a sensitive method.
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-023-03629-9