Strabismus outcomes in pediatric patients undergoing disconnective hemispheric surgery for intractable epilepsy: a systematic review

• Published in: Canadian journal of ophthalmology 2024-10, Vol.59 (5), p.e547
• Main Authors: Pur, Daiana R., Sivakumar, Gayathri K., Bursztyn, Lulu L.C.D., Iordanous, Yiannis, de Ribaupierre, Sandrine
• Format: Article
• Language: English
• Subjects: Adolescent; Child; Child, Preschool; Drug Resistant Epilepsy - surgery; Hemispherectomy; Humans; Oculomotor Muscles - physiopathology; Oculomotor Muscles - surgery; Postoperative Complications - epidemiology; Strabismus - physiopathology; Strabismus - surgery; Vision, Binocular - physiology
• ISSN: 0008-4182; 1715-3360; 1715-3360
• DOI: 10.1016/j.jcjo.2023.07.021

Children undergoing hemispheric surgery for intractable seizures are susceptible to visual complications including strabismus. This systematic review aims to investigate the rates and characteristics of strabismus development after hemispheric surgery and evaluate clinical implications for ophthalmologic care. A systematic search of MEDLINE, EMBASE, Cochrane, PsychINFO, and Web of Science databases was performed from database inception to May 2022. Included articles referred to strabismus outcomes in pediatric populations after hemispherectomy or hemispherotomy. Reviews and non-English-language publications were excluded. Risk of bias was assessed using Joanna Briggs Institute critical appraisal tools. Demographic data and characteristics of strabismus were extracted and tabulated. Of 41 articles identified, 10 studies consisting of 384 pediatric participants (48% females) and age at surgery between 6 months and 16 years were included. Preoperative strabismus rates ranged between 3% and 56%, whereas postoperative rates ranged between 38% and 100%. With respect to the site of hemispheric surgery, contralateral exodeviation was the most common (16%–67%; n = 7) and then ipsilateral exodeviation (16%–56%; n = 2), whereas ipsilateral esodeviation was infrequent (4%–9%; n = 3). Contralateral exotropia and ipsilateral esotropia may occur after hemispheric surgery and may have the potential to be field expanding. Concerns regarding negative social reactions should be balanced with the risk of visual field reduction and (or) diplopia by strabismus surgery. Higher-quality articles with large, homogeneous, and well-described populations (i.e., complete pre- and postoperative ophthalmologic assessments) are required to establish the risks and rates of strabismus development after hemispheric surgery.