Synthesis of rare-earth metal-organic frameworks to construct high-resolution sensing array for multiplex anions detection, cell imaging and blood phosphorus monitoring

• Published in: Journal of colloid and interface science 2023-12, Vol.652, p.1925-1936
• Main Authors: Shen, Gongle, Zhong, Linling, Liu, Guizhu, Yang, Liu, Wen, Xin, Chen, Guanxi, Zhao, Jiangqi, Hou, Changjun, Wang, Xianfeng
• Format: Article
• Language: English
• Subjects: Anions detection; Fluorescence detection; Pattern recognition; Rare-earth metal-organic frameworks; Sensing array
• ISSN: 0021-9797; 1095-7103
• DOI: 10.1016/j.jcis.2023.09.010

[Display omitted] •Four novel RE-MOFs were successfully designed and prepared.•Host-guest responses occurred between RE-MOFs and seven anions.•RE-MOFs nanoprobes were applied for construction of a sensing array for multiplex anions determination via pattern recognition.•RE-MOFs nanoprobes exhibit successful applications in quality monitoring of toothpaste, intracellular phosphate imaging, and blood phosphorus detection. Accurate detection and differentiation of multiple anions is still a difficult problem due to their wide variety, structural similarity, and mutual interference. Hence, four rare-earth metal-organic frameworks (RE-MOFs) including Dy-MOFs, Er-MOFs, Tb-MOFs and Y-MOFs are successfully prepared by using TCPP as the ligand and rare-earth ions as the metal center via coordination chelation. It is found that 7 anions can light up their fluorescence. Thus, a high-resolution sensing array based on RE-MOFs nanoprobes is employed to differentiate these anions from intricate analytes in real-time scenarios. The distinctive host-guest response promotes the RE-MOFs nanoprobes to selectively extract the target anions from the complex samples. By taking advantage of the cross-response between RE-MOFs nanoprobes and anions, it allows to create an array for detecting target analytes using pattern recognition. Additionally, RE-MOFs nanoprobes also facilitate the quantitative analysis of these anions (PO43−, H2PO4−, HPO42−, F−, S2−, CO32– and C2O42−). More importantly, the exceptional effectiveness of this method has been demonstrated through various successful applications, including quality monitoring of 8 toothpaste brands, intracellular phosphate imaging, and blood phosphorus detection in mice with vascular calcification. These findings provide robust evidence for the efficacy and reliability of the RE-MOFs nanoprobes array for anion recognition.