Nerve growth factor and angiotensin converting enzyme 2 levels in children with neurodevelopmental disorders

• Published in: International journal of neuroscience 2024-11, Vol.134 (11), p.1235-1241
• Main Authors: Gul, Melike Kevser, Sahin, Murside, Demirci, Esra, Ozmen, Sevgi, Tahtasakal, Reyhan, Sener, Elif Funda
• Format: Article
• Language: English
• Subjects: Adolescent; Angiotensin-Converting Enzyme 2 - blood; Attention Deficit Disorder with Hyperactivity - blood; Attention Deficit Disorder with Hyperactivity - diagnosis; Autism Spectrum Disorder - blood; Biomarkers - blood; Child; Child, Preschool; Female; Humans; Intellectual Disability - blood; Male; Nerve Growth Factor - blood; Neurodevelopmental Disorders - blood; Neurodevelopmental Disorders - diagnosis; Peptidyl-Dipeptidase A - blood
• ISSN: 0020-7454; 1563-5279; 1563-5279; 1543-5245
• DOI: 10.1080/00207454.2023.2257871

Neurodevelopmental disorders (NDDs) are the most common psychiatric disorders in childhood, and there are many factors in their etiology. In recent years, many biomarkers have been studied to elucidate the etiology of these disorders. In this study, it was aimed to investigate the levels of nerve growth factor (NGF) and angiotensin converting enzyme 2 (ACE2) in attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and intellectual disability (ID). The study included 74 children with NDDs (the number of patients in ADHD, ASD and ID groups were 24, 25 and 25 respectively) and 30 healthy controls (HCs). Serum NGF and ACE2 levels were studied with ELISA kits, also complete blood count (CBC), levels of fasting glucose and serum lipids were assessed. ACE2 levels were found to be lower in NDD group than HCs in girls. In boys with ASD, triglyceride levels were significantly higher than other groups. Also a positive correlation was found between ACE2 and NGF levels when all sample assessed together. This study is a premise for investigating ACE2 and NGF in NDDs. The role of these markers in ADHD, ASD, ID and other NDDs and their associations with gender should be assessed by studies in which both larger sample groups and more disorders.