Pregnancy, delivery and neonatal outcomes among women with hypoparathyroidism—A population‐based study

ObjectiveData are inconclusive regarding pregnancy complications associated with maternal chronic hypoparathyroidism. Therefore, we aimed to compare pregnancy, delivery and neonatal outcomes in patients affected by chronic hypoparathyroidism to those without chronic hypoparathyroidism.DesignA retros...

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Published in:Clinical endocrinology (Oxford) 2023-12, Vol.99 (6), p.525-532
Main Authors: Hochberg, Alyssa, Pare, Aurelie, Badeghiesh, Ahmad M., Baghlaf, Haitham A., Dahan, Michael H.
Format: Article
Language:English
Subjects:
Blood transfusion
Blood transfusions
Congenital defects
Diabetes mellitus
Hypoparathyroidism
Neonates
Population studies
Population-based studies
Pregnancy
Pregnancy complications
Premature birth
Risk factors
Thyroid diseases
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Summary:ObjectiveData are inconclusive regarding pregnancy complications associated with maternal chronic hypoparathyroidism. Therefore, we aimed to compare pregnancy, delivery and neonatal outcomes in patients affected by chronic hypoparathyroidism to those without chronic hypoparathyroidism.DesignA retrospective population‐based study utilising data from the Healthcare Cost and Utilization Project Nationwide Inpatient Sample (HCUP‐NIS) database over 11 years from 2004 to 2014 inclusively. Multivariate logistic regression was used to control for confounders.PatientsPatients with chronic hypoparathyroidism compared with those without.MeasurementsObstetric and neonatal outcomes.ResultsWe identified 204 pregnancies in mothers with chronic hypoparathyroidism and 9,096,584 pregnancies without chronic hypoparathyroidism. After adjusting for age, insurance plan type, obesity, chronic hypertension, thyroid disease, pregestational diabetes mellitus, and previous caesarean section, patients in the hypoparathyroidism group, compared with those without hypoparathyroidism, were found to have an increased rate of preterm birth (
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.14969