Schiff Base Reaction in a Living Cell: In Situ Synthesis of a Hollow Covalent Organic Polymer To Regulate Biological Functions

Artificially performing chemical reactions in living biosystems to attain various physiological aims remains an intriguing but very challenging task. In this study, the Schiff base reaction was conducted in cells using Sc(OTf) 3 as a catalyst, enabling the in situ synthesis of a hollow covalent orga...

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Published in:Angewandte Chemie International Edition 2023-10, Vol.62 (44), p.e202311002-e202311002
Main Authors: Xu, Han‐Bin, Chen, Hua‐Ying, Lv, Jian, Chen, Bin‐Bin, Zhou, Ze‐Rui, Chang, Shuai, Gao, Ya‐Ting, Huang, Wen‐Fei, Ye, Ming‐Jie, Cheng, Zi‐Jian, Hafez, Mahmoud Elsayed, Qian, Ruo‐Can, Li, Da‐Wei
Format: Article
Language:English
Subjects:
Actin
Apoptosis
Catalysts
Cell fate
Chemical reactions
Chemical synthesis
External stimuli
Imines
Intracellular
Necroptosis
Polymers
Ripening
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Summary:Artificially performing chemical reactions in living biosystems to attain various physiological aims remains an intriguing but very challenging task. In this study, the Schiff base reaction was conducted in cells using Sc(OTf) 3 as a catalyst, enabling the in situ synthesis of a hollow covalent organic polymer (HCOP) without external stimuli. The reversible Schiff base reaction mediated intracellular Oswald ripening endows the HCOP with a spherical, hollow porous structure and a large specific surface area. The intracellularly generated HCOP reduced cellular motility by restraining actin polymerization, which consequently induced mitochondrial deactivation, apoptosis, and necroptosis. The presented intracellular synthesis system inspired by the Schiff base reaction has strong potential to regulate cell fate and biological functions, opening up a new strategic possibility for intervening in cellular behavior.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202311002