Loading…

The effectiveness of a transitional pain service in patients undergoing surgery with an increased risk of developing chronic postsurgical pain (TRUSt study). A randomized clinical trial

Poorly controlled acute postsurgical pain is associated with delayed recovery, chronic postsurgical pain (CPSP), chronic opioid use and impaired functioning in daily activities. The aim was to determine the effectiveness of a transitional pain service (TPS) to improve quality of recovery for patient...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical anesthesia 2023-12, Vol.91, p.111262-111262, Article 111262
Main Authors: Admiraal, Manouk, Hermanides, Jeroen, Meinsma, Soe L., Wartenberg, Hans C.H., Rutten, Martin V.H., Heine, Yvonne, Kallewaard, Jan Willem, Hollmann, Markus W., Hermanns, Henning
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Poorly controlled acute postsurgical pain is associated with delayed recovery, chronic postsurgical pain (CPSP), chronic opioid use and impaired functioning in daily activities. The aim was to determine the effectiveness of a transitional pain service (TPS) to improve quality of recovery for patients at risk of CPSP. We hypothesized that a TPS improves the quality of recovery in patients at risk of CPSP. Single-center, pragmatic, randomized, superiority trial. Tertiary hospital in the Netherlands. Assessed for eligibility if ≥18 years of age, undergoing elective surgery, and had an increased risk of developing CPSP. After being stratified for sex, 176 patients were included. Patients were randomized to receive TPS or standard of care (SOC). TPS was a multidisciplinary intervention providing a patient-tailored perioperative pain management plan, throughout all phases of surgery. The primary outcome was the difference in quality of recovery on the third postoperative day, measured by the Quality of Recovery (QoR)-15 questionnaire. Secondary outcomes include the between group differences in opioid consumption. The primary outcome was available in 169 (96.0%) patients. No difference between groups was found in QoR-15 on the third postoperative day (mean difference 2.0, 95% CI -5.5 to 9.4, p = 0.607). A decrease in opioid usage (compared to baseline) was observed in chronic opioid users, the median [IQR] reduction in total daily oral morphine milligram equivalents (MME) for TPS was −30 [−60, 0] at three and − 29.3 [−65.6, 0] at six months, whereas SOC had a median reduction of 0 [−56, 0] at three, and 0 [−60, 7.5] at six months. TPS did not significantly affect short-term quality of recovery but might improve long-term outcomes, such as the incidence of chronic pain, opioid consumption, and functioning in daily life. However, sample size in the present study was too small to provide solid evidence for this positive signal. •The Transitional Pain Service (TPS) could optimize perioperative pain management.•RCTs investigating the effectiveness of a TPS have not been conducted yet.•In this RCT which included 176 patients, TPS did not improve quality of recovery.•TPS might improve long-term outcomes such as opioid consumption.•Limited support for positive long-term outcomes due to the small sample size.
ISSN:0952-8180
1873-4529
DOI:10.1016/j.jclinane.2023.111262