Aromatic nitrogen scanning by ipso -selective nitrene internalization

Nitrogen scanning in aryl fragments is a valuable aspect of the drug discovery process, but current strategies require time-intensive, parallel, bottom-up synthesis of each pyridyl isomer because of a lack of direct carbon-to-nitrogen (C-to-N) replacement reactions. We report a site-directable aryl...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2023-09, Vol.381 (6665), p.1474-1479
Main Authors: Pearson, Tyler J., Shimazumi, Ryoma, Driscoll, Julia L., Dherange, Balu D., Park, Dong-Il, Levin, Mark D.
Format: Article
Language:English
Subjects:
Aromatic compounds
Drug development
Internalization
Molecular structure
Nitrogen
Oxidants
Oxidizing agents
Photochemicals
Pyridines
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