Pediatric Multiple Sclerosis: Changing the Trajectory of Progression

Purpose of Review Multiple sclerosis is a chronic inflammatory disease of the central nervous system. When seen in children and adolescents, crucial stages of brain development and maturation may be affected. Prompt recognition of multiple sclerosis in this population is essential, as early interven...

Full description

Saved in:
Bibliographic Details
Published in:Current neurology and neuroscience reports 2023-11, Vol.23 (11), p.657-669
Main Authors: Castillo Villagrán, Daniela, Yeh, E. Ann
Format: Article
Language:English
Subjects:
Adolescent
Central nervous system
Child
Developmental stages
Diagnosis, Differential
Differential diagnosis
Disease Progression
Humans
Inflammatory diseases
Medicine
Medicine & Public Health
Multiple sclerosis
Multiple Sclerosis - drug therapy
Multiple Sclerosis - therapy
Neurology
Neurosciences
Pediatrics
Review
Structure-function relationships
Topical Collection on Demyelinating Disorders
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose of Review Multiple sclerosis is a chronic inflammatory disease of the central nervous system. When seen in children and adolescents, crucial stages of brain development and maturation may be affected. Prompt recognition of multiple sclerosis in this population is essential, as early intervention with disease-modifying therapies may change developmental trajectories associated with the disease. In this paper, we will review diagnostic criteria for pediatric multiple sclerosis, outcomes, differential diagnosis, and current therapeutic approaches. Recent Findings Recent studies have demonstrated the utility of newer structural and functional metrics in facilitating early recognition and diagnosis of pediatric MS. Knowledge about disease-modifying therapies in pediatric multiple sclerosis has expanded in recent years: important developmental impacts of earlier therapeutic intervention and use of highly effective therapies have been demonstrated. Summary Pediatric MS is characterized by highly active disease and high disease burden. Advances in knowledge have led to early identification, diagnosis, and treatment. Lifestyle-related interventions and higher efficacy therapies are currently undergoing investigation.
ISSN:1528-4042
1534-6293
DOI:10.1007/s11910-023-01300-3