Viral dissemination and immune activation modulate antiretroviral drug levels in lymph nodes of SIV-infected rhesus macaques

To understand the relationship between immunovirological factors and antiretroviral (ARV) drug levels in lymph nodes (LN) in HIV therapy, we analyzed drug levels in twenty-one SIV-infected rhesus macaques subcutaneously treated with daily tenofovir (TFV) and emtricitabine (FTC) for three months. The...

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Published in:	Frontiers in immunology 2023-09, Vol.14, p.1213455
Main Authors:	Srinivasula, Sharat, Degrange, Paula, Perazzolo, Simone, Bonvillain, Andrew, Tobery, Amanda, Kaplan, Jacob, Jang, Hyukjin, Turnier, Refika, Davies, Michael, Cottrell, Mackenzie, Ho, Rodney J. Y., Di Mascio, Michele
Format:	Article
Language:	English
Subjects:	Animals Anti-Retroviral Agents - therapeutic use Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Antiviral agents Biopsy COVID-19 Disease prevention drug metabolite Drug therapy Emtricitabine Emtricitabine - therapeutic use HIV HIV Infections - drug therapy HIV Infections - prevention & control Human immunodeficiency virus immune activation Immune response Immunology Immunosuppressive agents Infections Laboratory animals Leukocytes, Mononuclear Lymph Nodes Lymphatic system Macaca mulatta Metabolites Monoclonal antibodies Peripheral blood mononuclear cells Pharmacokinetics Plasma rhesus macaque SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 SIV infection Tenofovir Tenofovir - therapeutic use
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