Calcium score of the entire thoracic aorta is an independent predictor of all-cause mortality in patients referred to chest computed tomography

Background Thoracic arterial calcifications (TAC) are not routinely reported or quantified in chest CT scans. We aimed to evaluate the association between TAC of the entire thoracic aorta and all-cause mortality (ACM) in patients referred to standard chest CT. Methods A retrospective analysis of con...

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Bibliographic Details
Published in:The international journal of cardiovascular imaging 2024-01, Vol.40 (1), p.177-183
Main Authors: Brodov, Yafim, Massalha, Eias, Shemesh, Joseph, Chodick, Gabriel, Shalev, Varda, Guindy, Michal, Goitein, Orly
Format: Article
Language:English
Subjects:
Aged
Aorta
Aorta, Thoracic - diagnostic imaging
Aortic valve
Calcification
Calcification (ectopic)
Calcium
Cardiac Imaging
Cardiology
Chest
Computed tomography
Coronary Artery Disease
Coronary vessels
Female
Heart valves
Humans
Imaging
Male
Males
Malignancy
Medical imaging
Medicine
Medicine & Public Health
Mortality
Multivariate analysis
Original Paper
Predictive Value of Tests
Radiology
Regression analysis
Regression models
Retrospective Studies
Risk Assessment
Risk Factors
Thorax
Tomography, X-Ray Computed - methods
Vascular Calcification - diagnostic imaging
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Summary:Background Thoracic arterial calcifications (TAC) are not routinely reported or quantified in chest CT scans. We aimed to evaluate the association between TAC of the entire thoracic aorta and all-cause mortality (ACM) in patients referred to standard chest CT. Methods A retrospective analysis of consecutive standard chest CT scans (non-gated, non-contrast) for the quantification of TAC, CAC and aortic valve calcification. TAC was divided into 4 sample-derived categories (TAC 1 = 0, TAC 2 = 1–65, TAC 3 = 66–439 and TAC 4 ≥ 440). Data regarding ACM was retrieved from the health care provider database. Multivariate Cox proportional regression models were used to assess associations between the TAC categories and ACM. Results The study cohort included 415 patients (mean age 67 years, 52% male); 107 ACM events were recorded during a median follow-up of 9 years (inter-quartile range: 7.4–10.4). The rate of ACM was 13%, 25%, 32%, 41% according to TAC category ( p  
ISSN:1875-8312
1569-5794
1875-8312
1573-0743
DOI:10.1007/s10554-023-02971-2