A comparison between field measurements of vapour concentrations of plant protection products and predictions by the BROWSE model

• Published in: Regulatory toxicology and pharmacology 2023-12, Vol.145, p.105504-105504, Article 105504
• Main Authors: Butler Ellis, M. Clare, Felkers, Edgars, Adham, Sarah, Vinck, Anne-Kim, Bürling, Kathrin, Morgan, Neil
• Format: Article
• Language: English
• Subjects: Air concentration of pesticides; BROWSE model; Bystander; Exposure to vapour; Inhalation exposure; Non-dietary risk assessment; Pesticides; Plant protection products; Resident; Vapour pressure
• ISSN: 0273-2300; 1096-0295
• DOI: 10.1016/j.yrtph.2023.105504

A database of field measurements of air concentrations of pesticide active ingredients has previously been compiled by CropLife Europe with an aim to revise the default air concentration values and assumptions applied in assessing vapour exposure in the risk assessment of bystanders and residents. The BROWSE model, released in 2014, which is a regulatory risk assessment model that includes the exposure of residents and bystanders has a component relating to post-application vapour inhalation. Predictions of concentration deduced from exposures obtained using the BROWSE model were compared with field measurements of 24-h and 7-day average concentrations. The methodology for obtaining concentration estimates from the BROWSE model is described, and the criteria for including field studies in the comparison are given. The field data were adjusted to account for differences between the field experiment and the BROWSE scenario using factors derived from a separate plume dispersion model. This showed that BROWSE provides a satisfactory level of conservatism in determining potential exposures of residents and bystanders to vapour and could be a reliable alternative to replace the current EFSA approach for predicting vapour inhalation exposures for pesticides where no compound-specific data are available. •Analysis of data from 23 GLP-compliant air monitoring studies.•Review of assumptions and the factors impacting air concentration.•Comparison of data with model predictions of 24-h and 7-day average concentrations.•BROWSE provides a satisfactory level of conservatism in determining exposures of residents and bystanders to vapour.