Childhood adversity and accelerated reproductive events: a systematic review and meta-analysis

Accelerated female reproductive events represent the early onset of reproductive events involving puberty, menarche, pregnancy loss, first sexual intercourse, first birth, parity, and menopause. This study aimed to explore the association between childhood adversity and accelerated female reproducti...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2024-03, Vol.230 (3), p.315-329.e31
Main Authors: Ding, Wenqin, Xu, Yuxiang, Kondracki, Anthony J., Sun, Ying
Format: Article
Language:English
Subjects:
abuse
Adolescent
Adverse Childhood Experiences
Child
childhood adversity
Cross-Sectional Studies
Female
Humans
Infant, Newborn
life history theory
meta-analysis
Parturition
Pregnancy
Premature Birth
Reproduction
reproductive events
reproductive timing
systematic review
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Summary:Accelerated female reproductive events represent the early onset of reproductive events involving puberty, menarche, pregnancy loss, first sexual intercourse, first birth, parity, and menopause. This study aimed to explore the association between childhood adversity and accelerated female reproductive events. PubMed, Web of Science, and Embase were systematically searched from September 22, 2022 to September 23, 2022. Observational cohort, cross-sectional, and case–control studies in human populations were included if they reported the time of reproductive events for female individuals with experience of childhood adversity and were published in English. Two reviewers independently screened studies, obtained data, and assessed study quality, and conflicts were resolved by a third reviewer. Dichotomous outcomes were evaluated using meta-analysis, and pooled odds ratios and 95% confidence intervals were generated using random-effects models. Moderation analysis and meta-regression were used to investigate heterogeneity. In total, 21 cohort studies, 9 cross-sectional studies, and 3 case–control studies were identified. Overall, female individuals with childhood adversity were nearly 2 times more likely to report accelerated reproductive events than those with no adversity exposure (odds ratio, 1.91; 95% confidence interval, 1.33–2.76; I2=99.6%; P
ISSN:0002-9378
1097-6868
1097-6868
DOI:10.1016/j.ajog.2023.10.005