An expedition in the jungle of pluripotent stem cells of non-human primates

For nearly three decades, more than 80 embryonic stem cell lines and more than 100 induced pluripotent stem cell lines have been derived from New World monkeys, Old World monkeys, and great apes. In this comprehensive review, we examine these cell lines originating from marmoset, cynomolgus macaque,...

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Bibliographic Details
Published in:Stem cell reports 2023-11, Vol.18 (11), p.2016-2037
Main Authors: Anwised, Preeyanan, Moorawong, Ratree, Samruan, Worawalan, Somredngan, Sirilak, Srisutush, Jittanun, Laowtammathron, Chuti, Aksoy, Irene, Parnpai, Rangsun, Savatier, Pierre
Format: Article
Language:English
Subjects:
African green monkey
Animals
baboon
blastoid
bonobo
Cell Line
chimera
chimpanzee
Chlorocebus aethiops
cynomolgus monkey
embryonic stem cell
Expeditions
gorilla
induced pluripotent stem cell
Induced Pluripotent Stem Cells - metabolism
Macaca fascicularis
Macaca mulatta
marmoset
naive-state
orangutan
Pluripotent Stem Cells
rhesus monkey
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Summary:For nearly three decades, more than 80 embryonic stem cell lines and more than 100 induced pluripotent stem cell lines have been derived from New World monkeys, Old World monkeys, and great apes. In this comprehensive review, we examine these cell lines originating from marmoset, cynomolgus macaque, rhesus macaque, pig-tailed macaque, Japanese macaque, African green monkey, baboon, chimpanzee, bonobo, gorilla, and orangutan. We outline the methodologies implemented for their establishment, the culture protocols for their long-term maintenance, and their basic molecular characterization. Further, we spotlight any cell lines that express fluorescent reporters. Additionally, we compare these cell lines with human pluripotent stem cell lines, and we discuss cell lines reprogrammed into a pluripotent naive state, detailing the processes used to attain this. Last, we present the findings from the application of these cell lines in two emerging fields: intra- and interspecies embryonic chimeras and blastoids. This review delves into more than 180 primate embryonic and induced PSC lines from marmosets to orangutans. It covers derivation methods, molecular features, and the inclusion of fluorescent reporters. Comparisons with human pluripotent stem cells are discussed, highlighting pluripotent naive state reprogramming. Applications in chimeras and blastoids are also explored.
ISSN:2213-6711
2213-6711
DOI:10.1016/j.stemcr.2023.09.013